CDP-4-dehidro-6-dezoksiglukoza reduktaza
CDP-4-dehidro-6-dezoksiglukoza reduktaza | |||||||||
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Identifikatori | |||||||||
EC broj | 1.17.1.1 | ||||||||
CAS broj | 37256-87-4 | ||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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CDP-4-dehidro-6-dezoksiglukoza reduktaza (EC 1.17.1.1, CDP-4-keto-6-dezoksiglukoza reduktaza, citidin difosfo-4-keto-6-dezoksi-D-glukozna reduktaza, citidin difosfat 4-keto-6-dezoksi-D-glukozna 3-dehidrogenaza, CDP-4-keto-dezoksi-glukozna reduktaza, CDP-4-keto-6-dezoksi-D-glukoza-3-dehidrogenazna sistem, NAD(P)H:CDP-4-keto-6-dezoksi-D-glukozna oksidoreduktaza) je enzim sa sistematskim imenom CDP-4-dehidro-3,6-didezoksi-D-glukoza:NAD(P)+ 3-oksidoreduktaza.[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
- CDP-4-dehidro-3,6-didezoksi-D-glukoza + NAD(P)+ + H2O CDP-4-dehidro-6-dezoksi-D-glukoza + NAD(P)H + H+
Ovaj enzim se sastoji od dva proteina. Jedan formira enzim-vezani dodatak CDP-4-dehidro-6-dezoksiglukoze sa piridoksamin fosfatom, u kome je 3-hidroksi grupa uklonjena. Drugi katalizuje redukciju ovog adukta putem NAD(P)H i otpuštanje CDP-4-dehidro-3,6-didezoksi-D-glukoze i piridoksamin fosfata.
- ↑ Pape, H. and Strominger, J.L. (1969). „Enzymatic synthesis of cytidine diphosphate 3,6-dideoxyhexoses. V. Partial purification of the two protein components required for introduction of the 3-deoxy group”. J. Biol. Chem. 244: 3598-3604. PMID 4389672.
- ↑ Rubenstein, P.A. and Strominger, J.L. (1974). „Enzymatic synthesis of cytidine diphosphate 3,6-dideoxyhexoses. VII. Mechanistic roles of enzyme E1 and pyridoxamine 5′-phosphate in the formation of cytidine diphosphate-4-keto-3,6-dideoxy-D-glucose from cytidine diphosphate-4-keto-6-deoxy-D-glucose”. J. Biol. Chem. 249: 3776-3781. PMID 4152100.
- ↑ Liu, H.-W. and Thorson, J.S. (1994). „Pathways and mechanisms in the biogenesis of novel deoxysugars by bacteria”. Annu. Rev. Microbiol. 48: 223-256. PMID 7826006.
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