DNK-(apurinsko ili apirimidinsko mesto) lijaza
(Preusmjereno sa stranice AP site-DNA 5'-phosphomonoester-lyase)
DNK-(apurinsko ili apirimidinsko mesto) lijaza | |||||||||
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Identifikatori | |||||||||
EC broj | 4.2.99.18 | ||||||||
CAS broj | 61811-29-8 | ||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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DNK-(apurinsko ili apirimidinsko mesto) lijaza (EC 4.2.99.18, AP lijaza, AP endonukleaza klasa I, endodezoksiribonukleaza (apurinska ili apirimidinska), dezoksiribonukleaza (apurinska ili apirimidinska), E. coli endonukleaza III, fag-T4 UV endonukleaza, Micrococcus luteus UV endonukleaza, AP mesto-DNK 5'-fosfomonoestar-lijaza, X-zrak endonukleaza III) je enzim sa sistematskim imenom DNK-(apurinsko ili apirimidinsko mesto) 5'-fosfomonoestar-lijaza.[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
- C-O-P veza 3' vezana za apurinsko ili apirimidinsko mesto u DNK se razlaže reakcijom beta-eliminacije, čime se formira 3'-terminalno nezasićeni šećer i produkt sa terminalnim 5'-fosfatom
Ova grupa enzima se ranije smatrala endonukleazama.
- ↑ Bailly, V., Sente, B. and Verly, W.G. (1989). „Bacteriophage-T4 and Micrococcus luteus UV endonucleases are not endonucleases but β-elimination and sometimes -elimination catalysts”. Biochem. J. 259: 751-759. PMID 2471512.
- ↑ Bailly, V. and Verly, W.G. (1987). „Escherichia coli endonuclease III is not an endonuclease but a β-elimination catalyst”. Biochem. J. 242: 565-572. PMID 2439070.
- ↑ Bailly, V. and Verly, W.G. (1989). „AP endonucleases and AP lyases”. Nucleic Acids Res. 17: 3617-3618. PMID 2471157.
- ↑ Manoharan, M., Mazumder, A., Ransom, S.C., Gerlt, J.A. and Bolton, P.H. (1988). „Mechanism of UV endonuclease-V cleavage of abasic sites in DNA determined by C-13 labeling”. J. Am. Chem. Soc. 110: 2690-2691.
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