GDP-Man:Man2GlcNAc2-PP-dolihol alfa-1,6-manoziltransferaza
(Preusmjereno sa stranice ALG2 (gene name, ambiguous))
GDP-Man:Man2GlcNAc2-PP-dolihol alfa-1,6-manoziltransferaza | |||||||||
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Identifikatori | |||||||||
EC broj | 2.4.1.257 | ||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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GDP-Man:Man2GlcNAc2-PP-dolihol alfa-1,6-manoziltransferaza (EC 2.4.1.257, GDP-Man:Man2GlcNAc2-PP-Dol alfa-1,6-manoziltransferaza, Alg2 manoziltransferaza, ALG2 (gen), GDP-Man:Man1GlcNAc2-PP-dolihol manoziltransferaza) je enzim sa sistematskim imenom GDP-D-manoza:D-Man-alfa-(1->3)-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-difosfodolihol alfa-6-manoziltransferaza.[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
- GDP-D-manoza + D-Man-alfa-(1->3)-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-difosfodolihol GDP + D-Man-alfa-(1->3)-[D-Man-alfa-(1->6)]-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-difosfodolihol
Biosinteza of asparaginom vezanih glikoproteina koristi dolihil difosfat-vezani glikozilni donor.
- ↑ Kampf, M., Absmanner, B., Schwarz, M. and Lehle, L. (2009). „Biochemical characterization and membrane topology of Alg2 from Saccharomyces cerevisiae as a bifunctional α1,3- and 1,6-mannosyltransferase involved in lipid-linked oligosaccharide biosynthesis”. J. Biol. Chem. 284: 11900-11912. PMID 19282279.
- ↑ O'Reilly, M.K., Zhang, G. and Imperiali, B. (2006). „In vitro evidence for the dual function of Alg2 and Alg11: essential mannosyltransferases in N-linked glycoprotein biosynthesis”. Biochemistry 45: 9593-9603. PMID 16878994.
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