5,6-Dimetilbenzimidazol sintaza
(Preusmjereno sa stranice 5,6-dimetilbenzimidazolna sintaza)
5,6-Dimetilbenzimidazol sintaza | |||||||||
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Identifikatori | |||||||||
EC broj | 1.14.99.40 | ||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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5,6-Dimetilbenzimidazol sintaza (EC 1.14.99.40, BLUB) je enzim sa sistematskim imenom FMNH2 oksidoreduktaza (formira 5,6-dimetilbenzimidazol).[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
- FMNH2 + NADH + H+ + O2 5,6-dimetilbenzimidazol + D-eritroza 4-fosfat + NAD+ + drugi produkt
C-2 atom iza 5,6-dimetilbenzimidazola je izveden iz C-1' ribitilne grupe FMNH2, dok je 2-H iz ribitil 1'-pro-S vodonika. Drugi produkt može da bude barbiturna kiselina.
- ↑ Gray, M.J. and Escalante-Semerena, J.C. (2007). „Single-enzyme conversion of FMNH2 to 5,6-dimethylbenzimidazole, the lower ligand of B12”. Proc. Natl. Acad. Sci. USA 104: 2921-2926. PMID 17301238.
- ↑ Ealick, S.E. and Begley, T.P. (2007). „Biochemistry: molecular cannibalism”. Nature 446: 387-388. PMID 17377573.
- ↑ Taga, M.E., Larsen, N.A., Howard-Jones, A.R., Walsh, C.T. and Walker, G.C. (2007). „BluB cannibalizes flavin to form the lower ligand of vitamin B12”. Nature 446: #449-453. PMID 17377583.
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