2',3'-Ciklični-nukleotid 3'-fosfodiestaraza
(Preusmjereno sa stranice 2',3'-ciklična nukleotidna fosfohidrolaza)
2',3'-Ciklični-nukleotid 3'-fosfodiestaraza | |||||||||
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Identifikatori | |||||||||
EC broj | 3.1.4.37 | ||||||||
CAS broj | 60098-35-3 | ||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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2',3'-Ciklični-nukleotid 3'-fosfodiestaraza (EC 3.1.4.37, ciklična-CMP fosfodiesteraza, 2',3'-ciklična AMP fosfodiesteraza, ciklična 2',3'-nukleotidna 3'-fosfodiesteraza, ciklična 2',3'-nukleotidna fosfodiesteraza, 2',3'-ciklična nukleozid monofosfatna fosfodiesteraza, 2',3'-ciklična nukleotidna 3'-fosfohidrolaza, CNPaza, 2',3'-ciklična nukleotidna fosfohidrolaza, 2':3'-ciklična nukleotidna 3'-fosfodiesteraza, 2':3'-CNMP-3'-aza) je enzim sa sistematskim imenom nukleozid-2',3'-ciklična-fosfat 2'-nukleotidohidrolaza.[1][2][3][4][5] Ovaj enzim katalizuje sledeću hemijsku reakciju
- nukleozid 2',3'-ciklična fosfat + H2O nukleozid 2'-fosfat
Moždani enzim deluje na 2',3'-ciklična AMP brže nego na UMP ili CMP derivate.
- ↑ Drummond, G.I., Iyer, N.T. and Keith, J. (1962). „Hydrolysis of ribonucleoside 2′,3′-cyclic phosphates by a diesterase from brain”. J. Biol. Chem. 237: 3535-3539.
- ↑ Helfman, D.M. and Kuo, J.F. (1982). „A homogeneous cyclic CMP phosphodiesterase hydrolyzes both pyrimidine and purine cyclic 2′:3′- and 3′:5′-nucleotides”. J. Biol. Chem. 257: 1044-1047. PMID 6274851.
- ↑ Helfman, D.M., Shoji, M. and Kuo, J.F. (1981). „Purification to homogeneity and general properties of a novel phosphodiesterase hydrolyzing cyclic CMP and cyclic AMP”. J. Biol. Chem. 256: 6327-6334. PMID 6263914.
- ↑ Kurihara, T., Nishizawa, Y., Takahashi, Y. and Odani, S. (1981). „Chemical, immunological and catalytic properties of 2′:3′-cyclic nucleotide 3′-phosphodiesterase purified from brain white matter”. Biochem. J. 195: 153-157. PMID 6272743.
- ↑ Nishizawa, Y., Kurihara, T. and Takahashi, Y. (1980). „Spectrophotometric assay, solubilization and purification of brain 2′:3′-cyclic nucleotide 3′-phosphodiesterase”. Biochem. J. 191: 71-82. PMID 6258586.
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