Xaa-Xaa-Pro tripeptidilna peptidaza
Prijeđi na navigaciju
Prijeđi na pretragu
| Xaa-Xaa-Pro tripeptidilna peptidaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.4.14.12 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Xaa-Xaa-Pro tripeptidilna peptidaza (EC 3.4.14.12, proliltripeptidilna aminopeptidaza, proliltripeptidilna peptidaza, PTP-A, TPP) je enzim.[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
- Hidroliza Xaa-Xaa-Pro--Yaa- uz odvajanje N-terminalnog tripeptida sa peptida koji ima Pro kao treći ostatak (pozicija P1) i gde Yaa nije prolin
Ova serin eksopeptidaza vezana za ćelijsku površinu je prisutna kod Gram-negativnih, anaerobnih bakterija Porphyromonas gingivalis.
Reference[uredi | uredi kod]
- ↑ Banbula, A., Mak, P., Bugno, M., Silberring, J., Dubin, A., Nelson, D., Travis, J. and Potempa, J. (1999). „Prolyl tripeptidyl peptidase from Porphyromonas gingivalis. A novel enzyme with possible pathological implications for the development of periodontitis”. J. Biol. Chem. 274: 9246-9252. PMID 10092598.
- ↑ Fujimura, S., Ueda, O., Shibata, Y. and Hirai, K. (2003). „Isolation and properties of a tripeptidyl peptidase from a periodontal pathogen Prevotella nigrescens”. FEMS Microbiol. Lett. 219: 305-309. PMID 12620636.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.