Xaa-Pro dipeptidilna peptidaza
Prijeđi na navigaciju
Prijeđi na pretragu
| Xaa-Pro dipeptidilna peptidaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.4.14.11 | ||||||||
| CAS broj | 54249-88-6 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Xaa-Pro dipeptidilna peptidaza (EC 3.4.14.11, X-prolil dipeptidilna aminopeptidaza, PepX, X-prolil dipeptidilna peptidaza, X-Pro dipeptidilna-peptidaza) je enzim.[1][2][3][4][5] Ovaj enzim katalizuje sledeću hemijsku reakciju
- Hidroliza Xaa-Pro veza uz odvajanje neblokiranih, N-terminalnih dipeptida. Supstrati su između ostalog Ala-Pro--p-nitroanilid i (sekvenciono) Tyr-Pro--Phe-Pro--Gly-Pro-Ile
Ovaj intraćelijski enzim iz Laktococcus lactis (190-kDa) pripada peptidaznoj familiji S15.
Reference[uredi | uredi kod]
- ↑ Zevaco, C., Monnet, V. and Gripon, J.-C. (1990). „Intracellular X-prolyl dipeptidyl peptidase from Lactococcus lactis' spp. lactis: purification and properties”. J. Appl. Bacteriol. 68: 357-366.
- ↑ Meyer-Barton, E.C., Klein, J.R., Imam, M. and Plapp, R. (1993). „Cloning and sequence analysis of the X-prolyl-dipeptidyl-aminopeptidase gene (pepX) from Lactobacillus delbrückii ssp. lactis DSM7290”. Appl. Microbiol. Biotechnol. 40: 82-89. PMID 7765315.
- ↑ Habibi-Najafi, M.B. and Lee, B.H. (1994). „Purification and characterization of X-prolyl dipeptidyl peptidase from Lactobacillus casei' subsp. casei LLG”. Appl. Microbiol. Biotechnol. 42: 280-286. PMID 7765768.
- ↑ Chich, J.-F., Gripon, J.-C. and Ribadeau-Dumas, B. (1995). „Preparation of bacterial X-prolyl dipeptidyl aminopeptidase and its stabilization by organic cosolvents”. Anal. Biochem. 224: 245-249. PMID 7710078.
- ↑ Chich, J.-F., Chapot-Chartier, M.P., Ribadeau-Dumas, B. and Gripon, J.-C. (1995). „Identification of the active site serine of the X-prolyl aminopeptidase from Lactococcus lactis'”. FEBS Lett. 314: 139-142.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.