WAY-100635

Izvor: Wikipedia
WAY-100635
(IUPAC) ime
N-[2-[4-(2-metoksifenil)-1-piperazinil]etil]- N-(2-piridil)cikloheksankarboksamid
Klinički podaci
Identifikatori
CAS broj 146714-97-8
ATC kod nije dodeljen
PubChem[1][2] 5684
ChEMBL[3] CHEMBL31354 YesY
Hemijski podaci
Formula C25H34N4O2 
Mol. masa 422,56 g/mol
SMILES eMolekuli & PubHem
Farmakoinformacioni podaci
Trudnoća  ?
Pravni status

WAY-100,635 je piperazinski lek koji je u širokoj upotrebi u naučnim istraživanjima. Za njega se originalno smatralo da deluje kao selektivni 5-HT1A antagonist, ali su naknadna istraživanja pokazala da on isto tako deluje kao potentan pun agonist na D4 receptoru.[4][5][6] On se ponekad naziva nemim antagonistom 5-HT1A receptora.[7] WAY-100,635 i WAY-100,135 su hemijski slični.

Reference[uredi - уреди]

  1. Li Q, Cheng T, Wang Y, Bryant SH (2010). "PubChem as a public resource for drug discovery.". Drug Discov Today 15 (23-24): 1052–7. doi:10.1016/j.drudis.2010.10.003. PMID 20970519.  edit
  2. Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). "Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities". Annual Reports in Computational Chemistry 4: 217–241. doi:10.1016/S1574-1400(08)00012-1. 
  3. Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). "ChEMBL: a large-scale bioactivity database for drug discovery". Nucleic Acids Res 40 (Database issue): D1100–7. doi:10.1093/nar/gkr777. PMID 21948594.  edit
  4. C. A. Fornal, C. W. Metzler, R. A. Gallegos, S. C. Veasey, A. C. McCreary and B. L. Jacobs (1996). "WAY-100635, a potent and selective 5-hydroxytryptamine1A antagonist, increases serotonergic neuronal activity in behaving cats: comparison with (S)-WAY-100135". The Journal of Pharmacology and Experimental Therapeutics 278 (2): 752–762. PMID 8768728. 
  5. Benjamin R. Chemel, Bryan L. Roth, Blaine Armbruster, Val J. Watts and David E. Nichols (October 2006). "WAY-100635 is a potent dopamine D4 receptor agonist". Psychopharmacology 188 (2): 244–251. doi:10.1007/s00213-006-0490-4. PMID 16915381. 
  6. Marona-Lewicka D, Nichols DE (2009). "WAY 100635 produces discriminative stimulus effects in rats mediated by dopamine D(4) receptor activation". Behav Pharmacol 20 (1): 114–8. doi:10.1097/FBP.0b013e3283242f1a. PMID 19179855. 
  7. A. Fletcher, E. A. Forster, D. J. Bill, G. Brown, I. A. Cliffe, J. E. Hartley, D. E. Jones, A. McLenachan, K. J. Stanhope, D. J. Critchley, K. J. Childs, V. C. Middlefell, L. Lanfumey, R. Corradetti, A. M. Laporte, H. Gozlan, M. Hamon & C. T. Dourish (1996). "Electrophysiological, biochemical, neurohormonal and behavioural studies with WAY-100635, a potent, selective and silent 5-HT1A receptor antagonist". Behavioural Brain Research 73 (1-2): 337–333. doi:10.1016/0166-4328(96)00118-0. PMID 8788530. 

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