Vanilil-alkohol oksidaza
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| Vanilil-alkohol oksidaza | |||||||||
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| Identifikatori | |||||||||
| EC broj | 1.1.3.38 | ||||||||
| CAS broj | 143929-24-2 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Vanilil-alkohol oksidaza (EC 1.1.3.38, 4-hidroksi-2-methoksibenzil alkohol oksidaza) je enzim sa sistematskim imenom vanilil alkohol:kiseonik oksidoreduktaza.[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
- vanilil alkohol + O2 vanillin +H2O2
Vanilil-alkoholna oksidaza iz Penicillium simplicissimum sadrži kovalentno vezani FAD. Ona konvertuje širok opseg 4-hidroksibenzil alkohola i 4-hidroksibenzilamina do korespondirajućih aldehida. Alil grupa 4-alilfenola se takođe konvertuje u -CH=CH-CH2OH grupu.
Reference[uredi | uredi kod]
- ↑ de Jong, E., van Berkel, W.J.H., van der Zwan, R.P. and de Bont, J.A.M. (1992). „Purification and characterization of vanillyl-alcohol oxidase from Penicillium simplicissimum, a novel aromatic alcohol oxidase containing covalently bound FAD”. Eur. J. Biochem. 208: 651-657. PMID 1396672.
- ↑ Fraaije, M.W., Veeger, C. and van Berkel, W.J.H. (1995). „Substrate specificity of flavin-dependent vanillyl-alcohol oxidase from Penicillium simplicissimum. Evidence for the production of 4-hydroxycinnamyl alcohols from 4-allylphenols”. Eur. J. Biochem. 234: 271-277. PMID 8529652.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.