Urokanatna hidrataza
(Preusmjereno sa stranice Urokanaza)
| Urokanatna hidrataza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
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| Identifikatori | |||||||||
| EC broj | 4.2.1.49 | ||||||||
| CAS broj | 9014-58-8 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Urokanatna hidrataza (EC 4.2.1.49, urokanaza, 3-(5-okso-4,5-dihidro-3H-imidazol-4-il)propanoat hidrolijaza) je enzim sa sistematskim imenom 3-(5-okso-4,5-dihidro-3H-imidazol-4-il)propanoat hidrolijaza (formira urokanat).[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
- 3-(5-okso-4,5-dihidro-3H-imidazol-4-il)propanoat urokanat + H2O
Ovaj enzim sadrži čvrsto vezani NAD+.
Reference[uredi | uredi kod]
- ↑ Rétey, J. (1994). „The urocanase story: a novel role of NAD+ as electrophile”. Arch. Biochem. Biophys. 314: 1-16. PMID 7944380.
- ↑ Hassall, H. and Greenberg, D.M. (1971). „Urocanase (beef liver)”. Methods Enzymol. 17B: 84-88.
- ↑ Kaminskas, E., Kimhi, Y. and Magasanik, B. (1970). „Urocanase and N-formimino-L-glutamate formiminohydrolase of Bacillus subtilis, two enzymes of the histidine degradation pathway”. J. Biol. Chem. 245: 3536-3544. PMID 4990470.
- ↑ Swaine, D. (1969). „The effect of substrate analogues on the activity of cat liver urocanase”. Biochim. Biophys. Acta 178: 609-618. PMID 5784906.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.