Undekaprenilna difosfataza
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| Undekaprenilna difosfataza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.6.1.27 | ||||||||
| CAS broj | 9077-80-9 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Undekaprenilna difosfataza (EC 3.6.1.27, C55-izoprenilna difosfataza, C55-izoprenilna pirofosfataza, izoprenilna pirofosfataza, undekaprenil pirofosfatna fosfataza, undekaprenil pirofosfatna pirofosfataza, UPP fosfataza, Und-PP pirofosfataza, UppP, BacA, undekaprenil-difosfatna fosfohidrolaza, undekaprenil-difosfataza) je enzim sa sistematskim imenom ditrans,oktacis-undekaprenil-difosfat fosfohidrolaza.[1][2][3][4][5][6] Ovaj enzim katalizuje sledeću hemijsku reakciju
- ditrans,oktacis-undekaprenil difosfat + H2O ditrans,oktacis-undekaprenil fosfat + fosfat
Ovaj enzim je izolovan iz bakterija Micrococcus lysodeikticus, Escherichia coli i Bacillus subtilis.
Reference[uredi | uredi kod]
- ↑ Goldman, R. and Strominger, J.L. (1972). „Purification and properties of C55-isoprenylpyrophosphate phosphatase from Micrococcus lysodeikticus”. J. Biol. Chem. 247: 5116-5122. PMID 4341539.
- ↑ El Ghachi, M., Bouhss, A., Blanot, D. and Mengin-Lecreulx, D. (2004). „The bacA gene of Escherichia coli encodes an undecaprenyl pyrophosphate phosphatase activity”. J. Biol. Chem. 279: 30106-30113. PMID 15138271.
- ↑ El Ghachi, M., Derbise, A., Bouhss, A. and Mengin-Lecreulx, D. (2005). „Identification of multiple genes encoding membrane proteins with undecaprenyl pyrophosphate phosphatase (UppP) activity in Escherichia coli”. J. Biol. Chem. 280: 18689-18695. PMID 15778224.
- ↑ Bernard, R., El Ghachi, M., Mengin-Lecreulx, D., Chippaux, M. and Denizot, F. (2005). „BcrC from Bacillus subtilis acts as an undecaprenyl pyrophosphate phosphatase in bacitracin resistance”. J. Biol. Chem. 280: 28852-28857. PMID 15946938.
- ↑ Tatar, L.D., Marolda, C.L., Polischuk, A.N., van Leeuwen, D. and Valvano, M.A. (2007). „An Escherichia coli undecaprenyl-pyrophosphate phosphatase implicated in undecaprenyl phosphate recycling”. Microbiology 153: 2518-2529. PMID 17660416.
- ↑ Touze, T., Blanot, D. and Mengin-Lecreulx, D. (2008). „Substrate specificity and membrane topology of Escherichia coli PgpB, an undecaprenyl pyrophosphate phosphatase”. J. Biol. Chem. 283: 16573-16583. PMID 18411271.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.