Ulp1 peptidaza
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| Ulp1 peptidaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.4.22.68 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Ulp1 peptidaza (EC 3.4.22.68, Smt3-protein konjugatna proteinaza, Ubl-specifična proteaza 1, Ulp1, Ulp1 endopeptidaza, Ulp1 proteaza) je enzim.[1][2][3][4][5][6] Ovaj enzim katalizuje sledeću hemijsku reakciju
- Hidroliza alfa-vezane peptidne veze u sekvenci Gly-Gly-Ala-Thr-Tyr na C-terminalnom kraju malog ubikvitinu sličnog modifikujućeg (SUMO) propeptid, Smt3, što dovodi do maturacije proteina. Druga reakcija je razlaganje epsilon-vezane peptidne veze između C-terminalnog glicina maturisanog SUMO i lizinske epsilon-amino grupe ciljnog proteina
Enzim iz Saccharomyces cerevisiae takođe može da prepozna mali ubikvitinu-sličan modifikator 1 (SUMO-1) ljudi kao supstrat.
Reference[uredi | uredi kod]
- ↑ Lima, C.D. (2004). „Ulp1 endopeptidase”. u: Barrett, A.J., Rawlings, N.D. and Woessner, J.F.. Handbook of Proteolytic Enzymes (2nd izd.). London: Elsevier. str. 1340-1344.
- ↑ Li, S.-J. and Hochstrasser, M. (1999). „A new protease required for cell-cycle progression in yeast”. Nature 398: 246-251. PMID 10094048.
- ↑ Taylor, D.L., Ho, J.C., Oliver, A. and Watts, F.Z. (2002). „Cell-cycle-dependent localisation of Ulp1, a Schizosaccharomyces pombe Pmt3 (SUMO)-specific protease”. J. Cell Sci. 115: 1113-1122. PMID 11884512.
- ↑ Li, S.-J. and Hochstrasser, M. (2003). „The Ulp1 SUMO isopeptidase: distinct domains required for viability, nuclear envelope localization, and substrate specificity”. J. Cell Biol. 160: 1069-1081. PMID 12654900.
- ↑ Ihara, M., Koyama, H., Uchimura, Y., Saitoh, H. and Kikuchi, A. (2007). „Noncovalent binding of small ubiquitin-related modifier (SUMO) protease to SUMO is necessary for enzymatic activities and cell growth”. J. Biol. Chem. 282: 16465-16475. PMID 17428805.
- ↑ Mukhopadhyay, D. and Dasso, M. (2007). „Modification in reverse: the SUMO proteases”. Trends Biochem. Sci. 32: 286-295. PMID 17499995.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.
- Lima, C.D. (2004). „Ulp1 endopeptidase”. u: Barrett, A.J., Rawlings, N.D. and Woessner, J.F.. Handbook of Proteolytic Enzymes (2nd izd.). London: Elsevier. str. 1340-1344.