UK-414,495

Izvor: Wikipedia
UK-414,495
(IUPAC) ime
(R)-2-({1-[(5-etil-1,3,4-tiadiazol-2-il)karbamoil]ciklopentil}metil)valerinska kiselina
Klinički podaci
Identifikatori
CAS broj 337962-93-3
ATC kod nije dodeljen
PubChem[1][2] 9949799
Hemijski podaci
Formula C16H25N3O3S 
Mol. masa 339,452 g/mol
SMILES eMolekuli & PubHem
Farmakoinformacioni podaci
Trudnoća  ?
Pravni status

UK-414,495 je lek koji je razvila kompanija Pfizer za tretman poremećaja ženskog seksualnog nadražaja.[3] UK-414,495 deluje kao potentan i selektivan inhibitor enzima neutralna endopeptidaza, čija normalna funkcija je razlaganje neuropeptida VIP. Konsekventno povećanje VIP aktivnosti menja protok krvi u genitalnom regionu, što dovodi do povećanja lubrikacije i mišične relaksacije.[4][5][6]

Reference[uredi - уреди]

  1. Li Q, Cheng T, Wang Y, Bryant SH (2010). "PubChem as a public resource for drug discovery.". Drug Discov Today 15 (23-24): 1052–7. doi:10.1016/j.drudis.2010.10.003. PMID 20970519.  edit
  2. Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). "Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities". Annual Reports in Computational Chemistry 4: 217–241. doi:10.1016/S1574-1400(08)00012-1. 
  3. 'Female Viagra' will help women increase their sexual arousal. Daily Mail Online 14th April 2010
  4. Armer R, Warne P, Witherington J (2006). "Recent disclosures of clinical drug candidates". Drug News & Perspectives 19 (1): 65–72. PMID 16550257.  ISSN 0214-0934
  5. Angulo J. (2010). "Neutral endopeptidase inhibition: could it have a role in the treatment of female sexual arousal disorder?". British Journal of Pharmacology 160: 48. doi:10.1111/j.1476-5381.2010.00693.x. 
  6. Wayman C., Baxter D., Turner L., Van Der Graaf P., Naylor A. (2010). "UK-414,495, a selective inhibitor of neutral endopeptidase, potentiates pelvic nerve-stimulated increases in female genital blood flow in the anaesthetized rabbit". British Journal of Pharmacology 160 (1): 51–59. doi:10.1111/j.1476-5381.2010.00691.x. PMC 2860206. PMID 20412068. 

Vidi još[uredi - уреди]

Spoljašnje veze[uredi - уреди]

Star of life.svg Molimo Vas, obratite pažnju na važno upozorenje u vezi tema o zdravlju (medicini).