UDP-N-acetilmuramoilalanil-tripeptid-D-alanil-D-alaninska ligaza
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| UDP-N-acetilmuramoilalanil-tripeptid-D-alanil-D-alaninska ligaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 6.3.2.10 | ||||||||
| CAS broj | 55354-36-4 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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UDP-N-acetilmuramoilalanil-tripeptid-D-alanil-D-alaninska ligaza (EC 6.3.2.10, MurF sintetaza, UDP-N-acetilmuramoil-L-alanil-D-glutamil-L-lizil-D-alanil-D-alanin sintetaza, UDP-N-acetilmuramoilalanil-D-glutamil-lizin-D-alanil-D-alanin ligaza, uridin difosfoacetilmuramoilpentapeptidna sintetaza, UDPacetilmuramoilpentapeptidna sintetaza, UDP-MurNAc-L-Ala-D-Glu-L-Lys:D-Ala-D-Ala ligaza) je enzim sa sistematskim imenom UDP-N-acetilmuramoil-L-alanil-D-glutamil-L-lizin:D-alanil-D-alanin ligaza (formira ADP).[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
- ATP + UDP-N-acetilmuramoil-L-alanil-gama-D-glutamil-L-lizin + D-alanil-D-alanin ADP + fosfat + UDP-N-acetilmuramoil-L-alanil-gama-D-glutamil-L-lizil-D-alanil-D-alanin
Ovaj enzim učestvuje u sintezi peptida ćelijskog zida.
Reference[uredi | uredi kod]
- ↑ Ito, E. and Strominger, J.L. (1962). „Enzymatic synthesis of the peptide in bacterial uridine nucleotides. II. Enzymatic synthesis and addition of D-alanyl-D-alanine”. J. Biol. Chem. 237: 2696-2703.
- ↑ van Heijenoort, J. (2001). „Recent advances in the formation of the bacterial peptidoglycan monomer unit”. Nat. Prod. Rep. 18: 503-519. PMID 11699883.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.