Tubulinilna Tyr karboksipeptidaza
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| Tubulinilna Tyr karboksipeptidaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.4.17.17 | ||||||||
| CAS broj | 73050-23-4 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Tubulinilna Tyr karboksipeptidaza (EC 3.4.17.17, karboksipeptidaza-tubulin, rastvorna karboksipeptidaza, tubulin-tirozinska karboksipeptidaza, tubulinska karboksipeptidaza, tubuliniltirozinska karboksipeptidaza, tirozinotubulinska karboksipeptidaza, tiroziltubulinska karboksipeptidaza, TTCPaze, moždana karboksipeptidaza I) je enzim.[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
- Razlaganje -Glu-Tyr veze čime se oslobađa C-terminalni tirozinski ostatak sa prirodno tirozinisanog tubulina. Neaktivan je na Z-Glu-Tyr
Ovaj enzim je aktivan pri neutralnom pH.
Reference[uredi | uredi kod]
- ↑ Argaraña, C.E., Barra, H.S. and Caputto, R. (1980). „Tubulinyl-tyrosine carboxypeptidase from chicken brain: properties and partial purification”. J. Neurochem. 34: 114-118. PMID 7452228.
- ↑ Kumar, N. and Flavin, M. (1981). „Preferential action of a brain detyrosinolating carboxypeptidase on polymerized tubulin”. J. Biol. Chem. 256: 7678-7686. PMID 6114100.
- ↑ Arce, C.A. and Barra, H.S. (1983). „Association of tubulinyl-tyrosine carboxypeptidase with microtubules”. FEBS Lett. 157: 75-78. PMID 6862022.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.