Triptaza

Izvor: Wikipedia
Triptaza
Identifikatori
EC broj 3.4.21.59
CAS broj 97501-93-4
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures

Triptaza (EC 3.4.21.59, mastocitna proteaza II, kožna triptaza, plućna triptaza, pljuvačna triptaza, mastocitna neutralna proteinaza, mastocitna triptaza, mastocitna neutralna proteinaza, mastocitna serinska proteinaza II, mastocitna proteinaza II, mastocitna serinska proteinazna triptaza, mastocitna proteaza II pacova, triptaza M) je enzim.[1][2][3][4][5] Ovaj enzim katalizuje sledeću hemijsku reakciju

Preferencijalno razlaganje veza: Arg-, Lys-, ali sa ograničenijom specifičnošću od tripsina

Ovaj enzim se javalja kao tetramerni molekul sa visokim afinitetom za heparin u mastocitnim granulama.

Reference[uredi - уреди]

  1. Tanaka, T., McRae, B.J., Cho, K., Cook, R., Fraki, J.E., Johnson, D.A. and Powers, J.C. (1983). "Mammalian tissue trypsin-like enzymes. Comparative reactivities of human skin tryptase, human lung tryptase, and bovine trypsin with peptide 4-nitroanilide and thioester substrates". J. Biol. Chem. 258: 13552–13557. PMID 6358206. 
  2. Kido, H., Fukusen, N. and Katunuma, N. (1985). "Chymotrypsin- and trypsin-type serine proteases in rat mast cells: properties and functions". Arch. Biochem. Biophys 239: 436–443. PMID 3890754. 
  3. Cromlish, J.A., Seidah, N.G., Marcinkiewitz, M., Hamelin, J., Johnson, D.A. and Chrétien, M. (1987). "Human pituitary tryptase: molecular forms, NH2-terminal sequence, immunocytochemical localization, and specificity with prohormone and fluorogenic substrates". J. Biol. Chem. 262: 1363–1373. PMID 3543004. 
  4. Harvima, I.T., Schechter, N.M., Harvima, R.J. and Fräki, J.E. (1988). "Human skin tryptase: purification, partial characterization and comparison with human lung tryptase". Biochim. Biophys. Acta 957: 71–80. PMID 3140898. 
  5. Vanderslice, P., Ballinger, S.M., Tam, E.K., Goldstein, S.M., Craik, C.S. and Caughey, G. (1990). "Human mast cell tryptase: multiple cDNAs and genes reveal a multigene serine protease family". Proc. Natl. Acad. Sci. USA 87: 3811–3815. PMID 2187193. 

Literatura[uredi - уреди]

Spoljašnje veze[uredi - уреди]