Trimetilamin monooksigenaza
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| Trimetilamin monooksigenaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.14.13.148 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Trimetilamin monooksigenaza (EC 1.14.13.148, flavinska monooksigenaza 3, FMO3, tmm (gen)) je enzim sa sistematskim imenom N,N,N-trimetilamin,NADPH:kiseonik oksidoreduktaza (formira N-oksid).[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
- N,N,N-trimetilamin + NADPH + H+ + O2 N,N,N-trimetilamin N-oksid + NADP+ + H2O
Ovaj enzim je flavoprotein. Bakterijski enzim omogućava bakterijama da koriste trimetilamin kao jedini izvor ugljenika i energije.
Reference[uredi | uredi kod]
- ↑ Large, P.J., Boulton, C.A. and Crabbe, M.J. (1972). „The reduced nicotinamide-adenine dinucleotide phosphate- and oxygen-dependent N-oxygenation of trimethylamine by Pseudomonas aminovorans”. Biochem. J. 128: 137P-138P. PMID 4404764.
- ↑ Dolphin, C.T., Riley, J.H., Smith, R.L., Shephard, E.A. and Phillips, I.R. (1997). „Structural organization of the human flavin-containing monooxygenase 3 gene (FMO3), the favored candidate for fish-odor syndrome, determined directly from genomic DNA”. Genomics 46: 260-267. PMID 9417913.
- ↑ Treacy, E.P., Akerman, B.R., Chow, L.M., Youil, R., Bibeau, C., Lin, J., Bruce, A.G., Knight, M., Danks, D.M., Cashman, J.R. and Forrest, S.M. (1998). „Mutations of the flavin-containing monooxygenase gene (FMO3) cause trimethylaminuria, a defect in detoxication”. Hum. Mol. Genet. 7: 839-845. PMID 9536088.
- ↑ Chen, Y., Patel, N.A., Crombie, A., Scrivens, J.H. and Murrell, J.C. (2011). „Bacterial flavin-containing monooxygenase is trimethylamine monooxygenase”. Proc. Natl. Acad. Sci. USA 108: 17791-17796. PMID 22006322.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.