Torasemid
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| (IUPAC) ime | |||
|---|---|---|---|
| 1- {4-[(3-metilfenil)amino]piridin-3-sulfonil3-(propan-2-il)ureja | |||
| Klinički podaci | |||
| Robne marke | Demadex, Luprac | ||
| AHFS/Drugs.com | Monografija | ||
| Identifikatori | |||
| CAS broj | 56211-40-6 | ||
| ATC kod | C03CA01 , C03CA04 | ||
| PubChem[1][2] | 41781 | ||
| DrugBank | DB00214 | ||
| ChemSpider[3] | 38123 | ||
| Hemijski podaci | |||
| Formula | C16H20N4O3S | ||
| Mol. masa | 348.42 | ||
| SMILES | eMolekuli & PubHem | ||
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| Fizički podaci | |||
| Tačka topljenja | 164-164 °C (-99 °F) | ||
| Farmakokinetički podaci | |||
| Poluvreme eliminacije | 3,5 sati | ||
| Izlučivanje | Hepatički metabilizam 80% | ||
| Farmakoinformacioni podaci | |||
| Trudnoća | ? | ||
| Pravni status | |||
| Način primene | Intravenozno; Oralno | ||
Torasemid (rINN) ili torsemid (USAN) je piridin-sulfonilurejni tip diuretika koji se uglavnom koristi za kontrolisanje otoka uzrokovanih kongestivnim zatajenjem srca. On takođe koristu u niskim dozama za kontrolu hipertenzije.[4][5][6][7]
Reference[uredi | uredi kod]
- ↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519.
- ↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
- ↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846.
- ↑ Dunn CJ, Fitton A, Brogden RN: Torasemide. An update of its pharmacological properties and therapeutic efficacy. Drugs. 1995 Jan;49(1):121-42. PMID 7705212
- ↑ FDA approved new drug bulletin: torsemide (Demadex), trimetrexate glucuronate (neuTrexin). RN. 1994 May;57(5):53-6. PMID 8197389
- ↑ Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS (2011). „DrugBank 3.0: a comprehensive resource for omics research on drugs”. Nucleic Acids Res. 39 (Database issue): D1035-41. PMID 21059682.
- ↑ Wishart DS, Knox C, Guo AC, Cheng D, Shrivastava S, Tzur D, Gautam B, Hassanali M (2008). „DrugBank: a knowledgebase for drugs, drug actions and drug targets”. Nucleic Acids Res 36 (Database issue): D901-6. PMID 18048412.
