Timidin kinaza
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| Timidin kinaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
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| Identifikatori | |||||||||
| EC broj | 2.7.1.21 | ||||||||
| CAS broj | 2594110 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Timidin kinaza (EC 2.7.1.21, timidinska kinaza (fosforilacija), 2'-dezoksitimidinska kinaza, dezoksitimidinska kinaza (fosforilacija)) je enzim sa sistematskim imenom ATP:timidin 5'-fosfotransferaza.[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
Dezoksiuridin takođe može da deluje kao akceptor. dGTP može da deluje kao donor.
Reference[uredi | uredi kod]
- ↑ Falke, D., Labenz, J., Brauer, D. and Muller, W.E.G. (1982). „Adenosine diphosphate: thymidine 5′-phosphotransferase, a new enzyme activity, associated with the Herpes simplex virus-induced deoxypyrimidine kinase”. Biochim. Biophys. Acta 708: 99-103. PMID 6293576.
- ↑ Kizer, D.E. and Holman, L. (1974). „Purification and properties of thymidine kinase from regenerating rat liver”. Biochim. Biophys. Acta 350: 193-200. PMID 4407348.
- ↑ Okazaki, R. and Kornberg, A. (1964). „Deoxythymidine kinase of Escherichia coli. I. Purification and some properties of the enzyme”. J. Biol. Chem. 239: 269-274. PMID 14114853.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.