Taurohenodezoksiholat 6α-hidroksilaza
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| Taurohenodezoksiholat 6α-hidroksilaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.14.13.97 | ||||||||
| CAS broj | 105669-85-0 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Taurohenodezoksiholat 6α-hidroksilaza (EC 1.14.13.97, CYP3A4, CYP4A21, taurohenodezoksiholat 6alfa-monooksigenaza) je enzim sa sistematskim imenom taurohenodezoksiholat,NADPH:kiseonik oksidoreduktaza (6alfa-hidroksilacija).[1][2][3][4][5][6] Ovaj enzim katalizuje sledeću hemijsku reakciju
- (1) taurohenodezoksiholat + NADPH + H+ + O2 taurohioholat + NADP+ + H2O
- (2) lithoholat + NADPH + H+ + O2 hiodezoksiholat + NADP+ + H2O
Ovaj enzim je hem-tiolatni protein (P-450). Za maksimalnu aktivnost je neophodan citohrom b5.
Reference[uredi | uredi kod]
- ↑ Araya, Z. and Wikvall, K. (1999). „6α-Hydroxylation of taurochenodeoxycholic acid and lithocholic acid by CYP3A4 in human liver microsomes”. Biochim. Biophys. Acta 1438: 47-54. PMID 10216279.
- ↑ Araya, Z., Hellman, U. and Hansson, R. (1995). „Characterisation of taurochenodeoxycholic acid 6α-hydroxylase from pig liver microsomes”. Eur. J. Biochem. 231: 855-861. PMID 7649186.
- ↑ Kramer, W., Sauber, K., Baringhaus, K.H., Kurz, M., Stengelin, S., Lange, G., Corsiero, D., Girbig, F., Konig, W. and Weyland, C. (2001). „Identification of the bile acid-binding site of the ileal lipid-binding protein by photoaffinity labeling, matrix-assisted laser desorption ionization-mass spectrometry, and NMR structure”. J. Biol. Chem. 276: 7291-7301. PMID 11069906.
- ↑ Lundell, K., Hansson, R. and Wikvall, K. (2001). „Cloning and expression of a pig liver taurochenodeoxycholic acid 6α-hydroxylase (CYP4A21): a novel member of the CYP4A subfamily”. J. Biol. Chem. 276: 9606-9612. PMID 11113117.
- ↑ Lundell, K. and Wikvall, K. (2003). „Gene structure of pig sterol 12α-hydroxylase (CYP8B1) and expression in fetal liver: comparison with expression of taurochenodeoxycholic acid 6α-hydroxylase (CYP4A21)”. Biochim. Biophys. Acta 1634: 86-96. PMID 14643796.
- ↑ Russell, D.W. (2003). „The enzymes, regulation, and genetics of bile acid synthesis”. Annu. Rev. Biochem. 72: 137-174. PMID 12543708.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.