TAN-67

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TAN-67
(IUPAC) ime
3-[(4aS,12aR)-11-amino-2-methyl-1,3,4,5,12,12a-hexahydropyrido[3,4-b]acridin-4a(2H)-yl]phenol
Klinički podaci
Identifikatori
CAS broj 148545-09-9
ATC kod ?
PubChem[1][2] 9798940
Hemijski podaci
Formula C23H25N3O 
Mol. masa 359.464 g/mol
SMILES eMolekuli & PubHem
Farmakoinformacioni podaci
Trudnoća ?
Pravni status

TAN-67 (SB-205,607) je lek koji se koristi u naučnim istraživanjima. On je potentan i selektivan δ-opioidni agonist,[3] selektivan za δ1 tip receptora.[4] Ovaj materijal ima analgetska svojstva[5][6] i indukuje oslobađanje dopamina u mozgu.[7] On takođe štiti srčano i moždano tkivo od oštećenja tokom hipoksije putem više mehanizama među kojima je interakcija δ receptora i mitohondrijskih K(ATP) kanala.[8][9][10][11][12]

Reference[uredi | uredi kod]

  1. Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519.  edit
  2. Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1. 
  3. Fujii H, Kawai K, Kawamura K, Mizusuna A, Onoda Y, Murachi M, Tanaka T, Endoh T, Nagase H. Synthesis of optically active TAN-67, a highly selective delta opioid receptor agonist, and investigation of its pharmacological properties. Drug Design and Discovery. 2001;17(4):325-30. PMID 11765135
  4. Nagase H, Kawai K, Hayakawa J, Wakita H, Mizusuna A, Matsuura H, Tajima C, Takezawa Y, Endoh T. Rational drug design and synthesis of a highly selective nonpeptide delta-opioid agonist, (4aS*,12aR*)-4a-(3-hydroxyphenyl)-2-methyl- 1,2,3,4,4a,5,12,12a-octahydropyrido[3,4-b]acridine (TAN-67). Chemical and Pharmaceutical Bulletin (Tokyo). 1998 Nov;46(11):1695-702. PMID 9845952
  5. Yajima Y, Narita M, Tsuda M, Imai S, Kamei J, Nagase H, Suzuki T. Modulation of NMDA- and (+)TAN-67-induced nociception by GABA(B) receptors in the mouse spinal cord. Life Sciences. 2000 Dec 29;68(6):719-25. PMID 11205886
  6. Nagase H, Yajima Y, Fujii H, Kawamura K, Narita M, Kamei J, Suzuki T. The pharmacological profile of delta opioid receptor ligands, (+) and (-) TAN-67 on pain modulation. Life Sciences. 2001 Apr 6;68(19-20):2227-31. PMID 11358331
  7. Fusa K, Takahashi I, Watanabe S, Aono Y, Ikeda H, Saigusa T, Nagase H, Suzuki T, Koshikawa N, Cools AR. The non-peptidic delta opioid receptor agonist TAN-67 enhances dopamine efflux in the nucleus accumbens of freely moving rats via a mechanism that involves both glutamate and free radicals. Neuroscience. 2005;130(3):745-55. PMID 15590157
  8. Fryer RM, Hsu AK, Nagase H, Gross GJ. Opioid-induced cardioprotection against myocardial infarction and arrhythmias: mitochondrial versus sarcolemmal ATP-sensitive potassium channels. Journal of Pharmacology and Experimental Therapeutics. 2000 Aug;294(2):451-7. PMID 10900218
  9. Huh J, Gross GJ, Nagase H, Liang BT. Protection of cardiac myocytes via delta(1)-opioid receptors, protein kinase C, and mitochondrial K(ATP) channels. American Journal of Physiology. Heart and Circulatory Physiology. 2001 Jan;280(1):H377-83. PMID 11123254
  10. Patel HH, Ludwig LM, Fryer RM, Hsu AK, Warltier DC, Gross GJ. Delta opioid agonists and volatile anesthetics facilitate cardioprotection via potentiation of K(ATP) channel opening. FASEB Journal. 2002 Sep;16(11):1468-70. PMID 12205051
  11. Maslov LN, Platonov AA, Lasukova TV, Lishmanov IuB, Oeltgen P, Nagase H, Podoksenov IuK, Podoksenov AIu. Delta-opioid receptor activation prevents appearance of irreversible damages of cardiomyocytes and exacerbates myocardial contractility dysfunction during ischemia and reperfusion. Patologicheskaia Fiziologiia i Eksperimental'naia Terapiia. (Russian) 2006 Oct-Dec;(4):13-7. PMID 17300082
  12. Tian XS, Zhou F, Yang R, Xia Y, Wu GC, Guo JC. Effects of intracerebroventricular injection of delta-opioid receptor agonist TAN-67 or antagonist naltrindole on acute cerebral ischemia in rat. Sheng Li Xue Bao (Chinese). 2008 Aug 25;60(4):475-484. PMID 18690389

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