Sterol O-aciltransferaza
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| Sterol O-aciltransferaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.3.1.26 | ||||||||
| CAS broj | 9027-63-8 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Sterol O-aciltransferaza (EC 2.3.1.26, holestarolna aciltransferaza, sterol-estarska sintaza, sterol-estarska sintetaza, sterol-estarska sintaza, acil koenzim A-holestarol-O-aciltransferaza, acil-KoA:holestarol aciltransferaza, ACAT, acilkoenzim A:holestarol O-aciltransferaza, holestarol estarska sintaza, holestarol estarska sintetaza, holestaril estarska sintetaza) je enzim sa sistematskim imenom acil-KoA:holestarol O-aciltransferaza.[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
- acil-KoA + holesterol KoA + holesterol estar
Životinjski enzim je visoko specifičan za transfer acil grupa.
Reference[uredi | uredi kod]
- ↑ Sgoutas, D.S. (1970). „Effect of geometry and position of ethylenic bond upon acyl coenzymeA--cholesterol-O-acyltransferase”. Biochemistry 9: 1826-1833. PMID 5439042.
- ↑ Spector, A.A., Mathur, S.N. and Kaduce, T.L. (1979). „Role of acylcoenzyme A: cholesterol O-acyltransferase in cholesterol metabolism”. Prog. Lipid Res. 18: 31-53. PMID 42927.
- ↑ Taketani, S., Nishino, T. and Katsuki, H. (1979). „Characterization of sterol-ester synthetase in Saccharomyces cerevisiae”. Biochim. Biophys. Acta 575: 148-155. PMID 389289.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.