Steroid 17a-monooksigenaza
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| Steroid 17a-monooksigenaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.14.99.9 | ||||||||
| CAS broj | 9029-67-8 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Steroid 17a-monooksigenaza (EC 1.14.99.9, steroid 17alfa-hidroksilaza, citohrom P-45017alfa, citohrom P-450 (P-45017alfa,lijaza), 17alfa-hidroksilaza-C17,20 lijaza) je enzim sa sistematskim imenom steroid,vodonik-donor:kiseonik oksidoreduktaza (17alfa-hidroksilacija).[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
- steroid + AH2 + O2 17alfa-hidroksisteroid + A + H2O
Za rad ovog enzima je neophodan NAD(P)H i P-450.
Reference[uredi | uredi kod]
- ↑ Lynn, W.S. and Brown, R.H. (1958). „The conversion of progesterone to androgens by testes”. J. Biol. Chem. 232: 1015-1030. PMID 13549484.
- ↑ Yoshida, K.-I., Oshima, H. and Troen, P. (1980). „Studies of the human testis. XIII. Properties of nicotinamide adenine dinucleotide (reduced form)-linked 17α-hydroxylation”. J. Clin. Endocrinol. Metab. 50: 895-899. PMID 6966286.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.