Sortaza-B
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| Sortaza-B | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.4.22.71 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Sortaza-B (EC 3.4.22.71, SrtB) je enzim.[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
- Ovaj enzim katalizuje reakciju sortiranja ćelijskog zida u kojoj se površinski protein sa signalom sortiranja koji sadrži NXTN motif razlaže. Rezultirajući treonin karboksilni kraj proteina je kovalentno veza za pentaglicin peptidoglikana.
Ovaj enzim pripada peptidaznoj familiji C60.
Reference[uredi | uredi kod]
- ↑ Zong, Y., Mazmanian, S.K., Schneewind, O. and Narayana, S.V. (2004). „The structure of sortase B, a cysteine transpeptidase that tethers surface protein to the Staphylococcus aureus cell wall”. Structure 12: 105-112. PMID 14725770.
- ↑ Bierne, H., Garandeau, C., Pucciarelli, M.G., Sabet, C., Newton, S., Garcia-del Portillo, F., Cossart, P. and Charbit, A. (2004). „Sortase B, a new class of sortase in Listeria monocytogenes”. J. Bacteriol. 186: 1972-1982. PMID 15028680.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.