Serinska peptidaza ekvinskog arterivirusa

Izvor: Wikipedia
Serinska peptidaza ekvinskog arterivirusa
Identifikatori
EC broj 3.4.21.114
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures

Serinska peptidaza ekvinskog arterivirusa (EC 3.4.21.114, Equine arterivirus serine peptidase) je enzim.[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju

Presecanje (Glu/Gln)-(Gly/Ser/Ala) u translacionim produktima arterivirusne replikaze ORF1a i ORF1ab

U konjskom arterivirusu (EAV), gen replikaze se translira u otvorene okvire čitanja 1a (ORF1a) i ORF1ab poliproteina.

Reference[uredi - уреди]

  1. Snijder, E.J., Wassenaar, A.L., van Dinten, L.C., Spaan, W.J. and Gorbalenya, A.E. (1996). "The arterivirus nsp4 protease is the prototype of a novel group of chymotrypsin-like enzymes, the 3C-like serine proteases". J. Biol. Chem. 271: 4864–4871. PMID 8617757. 
  2. van Dinten, L.C., Rensen, S., Gorbalenya, A.E. and Snijder, E.J. (1999). "Proteolytic processing of the open reading frame 1b-encoded part of arterivirus replicase is mediated by nsp4 serine protease and is essential for virus replication". J. Virol. 73: 2027–2037. PMID 9971783. 
  3. Barrette-Ng, I.H., Ng, K.K., Mark, B.L., Van Aken, D., Cherney, M.M., Garen, C., Kolodenko, Y., Gorbalenya, A.E., Snijder, E.J. and James, M.N. (2002). "Structure of arterivirus nsp4. The smallest chymotrypsin-like proteinase with an α/β C-terminal extension and alternate conformations of the oxyanion hole". J. Biol. Chem. 277: 39960–39966. PMID 12163505. 

Literatura[uredi - уреди]

Spoljašnje veze[uredi - уреди]