Scitalidopepsin-B
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| Scitalidopepsin-B | |||||||||
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| Identifikatori | |||||||||
| EC broj | 3.4.23.32 | ||||||||
| CAS broj | 104781-89-7 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Scitalidopepsin-B (EC 3.4.23.32, Scytalidium aspartinska proteinaza B, Ganoderma lucidum karboksilna proteinaza, Ganoderma lucidum aspartinska proteinaza, Scytalidium lignicolum aspartinska proteinaza B, SLB) je enzim.[1][2][3][4][5] Ovaj enzim katalizuje sledeću hemijsku reakciju
- Hidroliza proteina sa širokom specifičnošću. Ralaže se Phe24-Phe, ali ne i Leu15-Tyr i Phe25-Tyr u B lancu insulina
Ovaj enzim je jedna od najmanjih aspartičkih endopeptidaza.
Reference[uredi | uredi kod]
- ↑ Terashita, T., Oda, K., Kono, M. and Murao, S. (1981). „Streptomyces pepsin inhibitor-insensitive carboxyl proteinase from Lentinus edodes”. Agric. Biol. Chem. 45: 1937-1943.
- ↑ Maita, T., Nagata, S., Matsuda, G., Maruta, S., Oda, K., Murao, S. and Tsuru, D. (1984). „Complete amino acid sequence of Scytalidium lignicolum acid protease B”. J. Biochem. (Tokyo) 95: 465-473. PMID 6370989.
- ↑ Terashita, T., Oda, K., Kono, M. and Murao, S. (1984). „Streptomyces pepsin inhibitor-insensitive carboxyl proteinase from Ganoderma lucidum”. Agric. Biol. Chem. 48: 1029-1035.
- ↑ Kobayashi, H., Kusakabe, I. and Murakami, K. (1985). „Purification and characterization of a pepstatin-insensitive carboxyl proteinase from Polyporus tulipiferae (Irpex lacteus)”. Agric. Biol. Chem. 49: 2393-2397.
- ↑ Tsuru, D., Shimada, S., Maruta, S., Yoshimoto, T., Oda, K., Murao, S., Miyata, T. and Iwanaga, S. (1986). „Isolation and amino acid sequence of a peptide containing an epoxide-reactive residue from the thermolysin-digest of Scytalidium lignicolum acid protease B”. J. Biochem. (Tokyo) 99: 1537-1539. PMID 3519605.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.