S-adenozilmetionin:tRNK riboziltransferaza-izomeraza
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| S-adenozilmetionin:tRNK riboziltransferaza-izomeraza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.4.99.17 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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S-adenozilmetionin:tRNK riboziltransferaza-izomeraza (EC 2.4.99.17, QueA enzim, kveozin biosinteza protein QueA) je enzim sa sistematskim imenom S-adenozil-L-metionin:7-aminometil-7-deazaguanozin riboziltransferaza (ribozil izomerizacija; L-metionin, otpuštanje adenina).[1][2][3][4][5][6] Ovaj enzim katalizuje sledeću hemijsku reakciju
- S-adenozil-L-metionin + 7-aminometil-7-karbaguanozin34 u tRNK L-metionin + adenin + epoksikveozin34 u tRNK
Ova reakcija je kombinovani transfer i izomerizacija ribozne grupe S-adenozil-L-metionina do modifikovanje guanozinske base u nestabilnoj poziciji tRNK molekula specifičnih za Tyr, His, Asp ili Asn.
Reference[uredi | uredi kod]
- ↑ Slany, R.K., Bosl, M., Crain, P.F. and Kersten, H. (1993). „A new function of S-adenosylmethionine: the ribosyl moiety of AdoMet is the precursor of the cyclopentenediol moiety of the tRNA wobble base queuine”. Biochemistry 32: 7811-7817. PMID 8347586.
- ↑ Slany, R.K., Bosl, M. and Kersten, H. (1994). „Transfer and isomerization of the ribose moiety of AdoMet during the biosynthesis of queuosine tRNAs, a new unique reaction catalyzed by the QueA protein from Escherichia coli”. Biochimie 76: 389-393. PMID 7849103.
- ↑ Kinzie, S.D., Thern, B. and Iwata-Reuyl, D. (2000). „Mechanistic studies of the tRNA-modifying enzyme QueA: a chemical imperative for the use of AdoMet as a "ribosyl" donor”. Org. Lett. 2: 1307-1310. PMID 10810734.
- ↑ Van Lanen, S.G. and Iwata-Reuyl, D. (2003). „Kinetic mechanism of the tRNA-modifying enzyme S-adenosylmethionine:tRNA ribosyltransferase-isomerase (QueA)”. Biochemistry 42: 5312-5320. PMID 12731872.
- ↑ Mathews, I., Schwarzenbacher, R., McMullan, D., Abdubek, P., Ambing, E., Axelrod, H., Biorac, T., Canaves, J.M., Chiu, H.J., Deacon, A.M., DiDonato, M., Elsliger, M.A., Godzik, A., Grittini, C., Grzechnik, S.K., Hale, J., Hampton, E., Han, G.W., Haugen, J., Hornsby, M., Jaroszewski, L., Klock, H.E., Koesema, E., Kreusch, A., Kuhn, P., Lesley, S.A., Levin, I., Miller, M.D., Moy, K., Nigoghossian, E., Ouyang, J., Paulsen, J., Quijano, K., Reyes, R., Spraggon, G., Stevens, R.C., van den Bedem, H., Velasquez, J., Vincent, J., White, A., Wolf, G., Xu, Q., Hodgson, K.O., Wooley, J. and Wilson, I.A. (2005). „Crystal structure of S-adenosylmethionine:tRNA ribosyltransferase-isomerase (QueA) from Thermotoga maritima at 2.0 Å resolution reveals a new fold”. Proteins 59: 869-874. PMID 15822125.
- ↑ Grimm, C., Ficner, R., Sgraja, T., Haebel, P., Klebe, G. and Reuter, K. (2006). „Crystal structure of Bacillus subtilis S-adenosylmethionine:tRNA ribosyltransferase-isomerase”. Biochem. Biophys. Res. Commun. 351: 695-701. PMID 17083917.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.