Ritipenem

Izvor: Wikipedia
Ritipenem
Klinički podaci
AHFS/Drugs.com Monografija
Identifikatori
ATC kod  ?
UNII D4SL77931L YesY
ChEMBL[1] CHEMBL70088 YesY
Hemijski podaci
Formula C10H12N2O6S 
Mol. masa 288,277
SMILES eMolekuli & PubHem
Farmakoinformacioni podaci
Trudnoća  ?
Pravni status

Ritipenem je organsko jedinjenje, koje sadrži 10 atoma ugljenika i ima molekulsku masu od 288,277 Da.

Osobine[uredi - уреди]

Osobina Vrednost
Broj akceptora vodonika 7
Broj donora vodonika 3
Broj rotacionih veza 5
Particioni koeficijent[2] (ALogP) -1,0
Rastvorljivost[3] (logS, log(mol/L)) -1,1
Polarna površina[4] (PSA, Å2) 155,5

Reference[uredi - уреди]

  1. Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). "ChEMBL: a large-scale bioactivity database for drug discovery". Nucleic Acids Res 40 (Database issue): D1100–7. doi:10.1093/nar/gkr777. PMID 21948594.  edit
  2. Ghose, A.K., Viswanadhan V.N., and Wendoloski, J.J. (1998). "Prediction of Hydrophobic (Lipophilic) Properties of Small Organic Molecules Using Fragment Methods: An Analysis of AlogP and CLogP Methods". J. Phys. Chem. A 102: 3762–3772. doi:10.1021/jp980230o. 
  3. Tetko IV, Tanchuk VY, Kasheva TN, Villa AE. (2001). "Estimation of Aqueous Solubility of Chemical Compounds Using E-State Indices". Chem Inf. Comput. Sci. 41: 1488–1493. doi:10.1021/ci000392t. PMID 11749573. 
  4. Ertl P., Rohde B., Selzer P. (2000). "Fast calculation of molecular polar surface area as a sum of fragment based contributions and its application to the prediction of drug transport properties". J. Med. Chem. 43: 3714–3717. doi:10.1021/jm000942e. PMID 11020286. 

Literatura[uredi - уреди]

Spoljašnje veze[uredi - уреди]