Ribonukleaza T1
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| Ribonukleaza T1 | |||||||||
|---|---|---|---|---|---|---|---|---|---|
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| Identifikatori | |||||||||
| EC broj | 3.1.27.3 | ||||||||
| CAS broj | 2603057 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Ribonukleaza T1 (EC 3.1.27.3, guaniloribonukleaza, Aspergillus oryzae ribonukleaza, RNaza N1, RNaza N2, ribonukleaza N3, ribonukleaza U1, ribonukleaza F1, ribonukleaza Ch, ribonukleaza PP1, ribonukleaza SA, RNaza F1, ribonukleaza C2, binaza, RNaza Sa, guanil-specifična RNaza, RNaza G, RNaza T1, ribonukleaza guaninnukleotido-2'-transferaza (ciklizacija), ribonukleaza N3, ribonukleaza N1) je enzim.[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
- Dvostepeno endonukleolitičko razlaganje do nukleozid 3'-fosfata i 3'-fosfooligonukleotida koji se završavaju sa Gp uz 2',3'-ciklično fosfatne intermedijere
Ovaj enzim je ranije bio klasifikovan kao EC 2.7.7.26 i EC 3.1.4.8.
Reference[uredi | uredi kod]
- ↑ Kasai, K., Uchida, T., Egami, F., Yoshida, K. and Nomoto, M. (1969). „Purification and crystallization of ribonuclease N1 from Neurospora crassa”. J. Biochem. (Tokyo) 66: 389-396. PMID 5348588.
- ↑ Takahashi, K. (1961). „The structure and function of ribonuclease T1. I. Chromatographic purification and properties of ribonuclease T1”. J. Biochem. (Tokyo) 49: 1-8.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.