Prostaglandin-F sintaza
| Prostaglandin-F sintaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.1.1.188 | ||||||||
| CAS broj | 55976-95-9 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Prostaglandin-F sintaza (EC 1.1.1.188, prostaglandin-D2 11-reduktaza, reduktaza, 15-hidroksi-11-oksoprostaglandin, PGD2 11-ketoreduktaza, PGF2alfa sintetaza, prostaglandin 11-ketoreduktaza, prostaglandin D2-ketoreduktaza, prostaglandin F sintaza, prostaglandin F sintetaza, sintetaza, prostaglandin F2alfa, PGF sintetaza, NADPH-zavisni prostaglandin D2 11-keto reduktaza, prostaglandin 11-keto reduktaza) je enzim sa sistematskim imenom (5Z,13E)-(15S)-9alfa,11alfa,15-trihidroksiprosta-5,13-dienoat:NADP+ 11-oksidoreduktaza.[1][2][3][4][5] Ovaj enzim katalizuje sledeću hemijsku reakciju
- (5Z,13E)-(15S)-9alfa,11alfa,15-trihidroksiprosta-5,13-dienoat + NADP+ (5Z,13E)-(15S)-9alfa,15-dihidroksi-11-oksoprosta-5,13-dienoat + NADPH + H+
Redukuje prostaglandin D2 i prostaglandin H2 do prostaglandina F2. Prostaglandin D2 nije intermedijer u redukciji prostaglandina H2. Takođe katalizuje redukciju brojnih karbonilnih jedinjenja, kao što je 9,10-fenantrohinon i 4-nitroacetofenon.
Reference[uredi | uredi kod]
- ↑ Reingold, D.F., Kawasaki, A. and Needleman, P. (1981). „A novel prostaglandin 11-keto reductase found in rabbit liver”. Biochim. Biophys. Acta 659: 179-188. PMID 7248318.
- ↑ Watanabe, K., Shimizu, T. and Hayaishi, O. (1981). „Enzymatic conversion of prostaglandin-D2 to prostaglandin-F2α in the rat lung”. Biochem. Int. 2: 603-610.
- ↑ Watanabe, K., Yoshida, R., Shimizu, T. and Hayaishi, O. (1985). „Enzymatic formation of prostaglandin F2α from prostaglandin H2 and D2. Purification and properties of prostaglandin F synthetase from bovine lung”. J. Biol. Chem. 260: 7035-7041. PMID 3858278.
- ↑ Wong, P.Y.-K. (1981). „Purification and partial characterization of prostaglandin D2 11-keto reductase in rabbit liver”. Biochim. Biophys. Acta 659: 169-178. PMID 7248317.
- ↑ Wong, P.Y.-K. (1982). „Purification of PGD2 11-ketoreductase from rabbit liver”. Methods Enzymol. 86: 117-125. PMID 7132748.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.