Prostaglandin-D sintaza
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| Prostaglandin-D sintaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 5.3.99.2 | ||||||||
| CAS broj | 65802-85-9 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Prostaglandin-D sintaza (EC 5.3.99.2, prostaglandin-H2 Delta-izomeraza, prostaglandin-R-prostaglandin D izomeraza, PGH-PGD izomeraza(5,13)-(15S)-9alfa,11alfa-epidioksi-15-hidroksiprosta-5,13-dienoat Delta-izomeraza, (5,13)-(15S)-9alfa,11alfa-epidioksi-15-hidroksiprosta-5,13-dienoat D-izomeraza, prostaglandin endoperoksid Delta-izomeraza, prostaglandin D sintetaza) je enzim sa sistematskim imenom (5Z,13E,15S)-9alfa,11alfa-epidioksi-15-hidroksiprosta-5,13-dienoat D-izomeraza.[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
- (5Z,13E,15S)-9alfa,11alfa-epidioksi-15-hidroksiprosta-5,13-dienoat (5Z,13E,15S)-9alfa,15-dihidroksi-11-oksoprosta-5,13-dienoat
Ovaj enzim uzrokuje otvaranje epidioksilnog mosta.
Reference[uredi | uredi kod]
- ↑ Christ-Hazelhof, E. and Nugteren, D.H. (1979). „Purification and characterisation of prostaglandin endoperoxide Δ-isomerase, a cytoplasmic, glutathione-requiring enzyme”. Biochim. Biophys. Acta 572: 43-51. PMID 32914.
- ↑ Shimizu, T., Yamamoto, S. and Hayaishi, O. (1979). „Purification and properties of prostaglandin D synthetase from rat brain”. J. Biol. Chem. 254: 5222-5228. PMID 109431.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.