Proproteinska konvertaza 1

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Proproteinska konvertaza 1
PDB 1kn6 EBI.jpg
Identifikatori
EC broj 3.4.21.93
CAS broj 99676-46-7
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures

Proproteinska konvertaza 1 (EC 3.4.21.93, prohormonska konvertaza 3, neuroendokrina konvertaza 1, PC1) je enzim.[1][2][3][4][5] Ovaj enzim katalizuje sledeću hemijsku reakciju

Izdvajanje proteinskih hormona, neuropeptida i renina iz njihovih prekursora, generalno putem hidrolize -Lys-Arg- veza

Oaj enzim je zavistan od Ca2+, i maksimalno je aktivan na pH 5.5.

Reference[uredi - уреди]

  1. Seidah, N.G., Gaspar, L., Mion, P., Marcinkiewicz, M., Mbikay, M. and Chrétien, M. (1990). "cDNA sequence of two distinct pituitary proteins homologous to Kex2 and furin gene products: tissue-specific mRNAs encoding candidates for pro-hormone processing proteinases". DNA Cell Biol. 9: 415–424. PMID 2169760. 
  2. Smeekens, S.P., Avruch, A.S., LaMendola, J., Chan, S.J. and Steiner, D.F. (1991). "Identification of a cDNA encoding a second putative prohormone convertase related to PC2 in AtT20 cells and islets of Langerhans". Proc. Natl. Acad. Sci. USA 88: 340–344. PMID 1988934. 
  3. Steiner, D.F., Smeekens, S.P., Ohagi, S. and Chan, S.J. (1992). "The new enzymology of precursor processing endoproteases". J. Biol. Chem. 267: 23435–23438. PMID 1429684. 
  4. Seidah, N.G. and Chrétien, M. (1994). "Pro-protein convertases of the subtilisin/kexin family". Methods Enzymol. 244: 175–188. PMID 7845206. 
  5. Jean, F., Basak, A., Dimaio, J., Seidah, N.G. and Lazure, C. (1995). "An internally quenched fluorogenic substrate of prohormone convertase 1 and furin leads to a potent prohormone convertase inhibitor". Biochem. J. 307: 689–695. PMID 7741698. 

Literatura[uredi - уреди]

Spoljašnje veze[uredi - уреди]