NAD+ ADP-riboziltransferaza
(Preusmjereno sa stranice Poli ADP ribozna polimeraza)
| NAD+ ADP-riboziltransferaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.4.2.30 | ||||||||
| CAS broj | 58319-92-9 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
NAD+ ADP-riboziltransferaza (EC 2.4.2.30, poli(ADP-riboza) sintaza, ADP-riboziltransferaza (polimerizacija), NAD ADP-riboziltransferaza, PARP, PARP-1, NAD+:poli(adenin-difosfat-D-ribozil)-akceptor ADP-D-ribozil-transferaza, NAD+:poli(adenozin-difosfat-D-ribozil)-akceptor ADP-D-ribozil-transferaza) je enzim sa sistematskim imenom NAD+:poli(ADP-D-ribozil)-akceptor ADP-D-ribozil-transferaza.[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
- NAD+ + (ADP-D-ribozil)N-akceptor nikotinamid + (ADP-D-ribozil)n+1-akceptor + H+
ADP-D-ribozilna grupa sa NAD+ se prenosi na akceptorsku karboksnu grupu histona ili samog enzima.
Reference[uredi | uredi kod]
- ↑ Ueda, K. and Hayaishi, O. (1985). „ADP-ribosylation”. Annu. Rev. Biochem. 54: 73-100. PMID 3927821.
- ↑ Ueda, K., Kawaichi, M. and Hayaishi, O. (1982). „Poly(ADP-ribose) synthetase”. u: Hayaishi, O. and Ueda, K.. ADP-Ribosylation Reactions: Biology and Medicine. London: Academic Press. str. 117-155.
- ↑ Ushiro, H., Yokoyama, Y. and Shizuta, Y. (1987). „Purification and characterization of poly (ADP-ribose) synthetase from human placenta”. J. Biol. Chem. 262: 2352-2357. PMID 2434482.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.
- Ueda, K., Kawaichi, M. and Hayaishi, O. (1982). „Poly(ADP-ribose) synthetase”. u: Hayaishi, O. and Ueda, K.. ADP-Ribosylation Reactions: Biology and Medicine. London: Academic Press. str. 117-155.