Poli(ADP-riboza) glikohidrolaza
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| Poli(ADP-riboza) glikohidrolaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.2.1.143 | ||||||||
| CAS broj | 9068-16-0 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Poli(ADP-riboza) glikohidrolaza (EC 3.2.1.143, Poly(ADP-ribose) glycohydrolase) je enzim.[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
- hidroliza poli(ADP-riboze) na glikozidnim (1-2') riboza-riboza vezama čime se formira slobodna ADP-riboza
Ovaj enzim je specifičan za (1-2') riboza-riboza veze poli(ADP-riboza).
Reference[uredi | uredi kod]
- ↑ Miwa, M. and Sugimura, T. (1971). „Splitting of the ribose-ribose linkage of poly(adenosine diphosphate-ribose) by a calf thymus extract”. J. Biol. Chem. 246: 6362-6364. PMID 4331388.
- ↑ Lin, W., Ame, J.C., Aboul-Ela, N., Jacobson, E.L. and Jacobson, M.K. (1997). „Isolation and characterization of the cDNA encoding bovine poly(ADP-ribose) glycohydrolase”. J. Biol. Chem. 272: 11895-11901. PMID 9115250.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.