Plasmaniletanolamin desaturaza
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| Plasmaniletanolamin desaturaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.14.99.19 | ||||||||
| CAS broj | 39391-13-4 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Plasmaniletanolamin desaturaza (EC 1.14.99.19, alkilacilglicerofosfoetanolaminska desaturaza, alkilacilglicero-fosforiletanolaminska dehidrogenaza, dehidrogenaza, alkil-acilglicerofosforiletanolamin, 1-O-alkil-2-acil-sn-glicero-3-fosforiletanolaminska desaturaza, 1-O-alkil 2-acil-sn-glicero-3-fosforiletanolaminska desaturaza) je enzim sa sistematskim imenom O-1-alkil-2-acil-sn-glicero-3-fosfoetanolamin,vodonik-donor:kiseonik oksidoreduktaza.[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju:
- O-1-alkil-2-acil-sn-glicero-3-fosfoetanolamin + AH2 + O2 O-1-alk-1-enil-2-acil-sn-glicero-3-fosfoetanolamin + A + 2H2O
Za rad ovog enzima je neophodan NADPH ili NADH.
Reference[uredi | uredi kod]
- ↑ Paltauf, F. and Holasek, A. (1973). „Enzymatic synthesis of plasmalogens. Characterization of the 1-O-alkyl-2-acyl-sn-glycero-3-phosphorylethanolamine desaturase from mucosa of hamster small intestine”. J. Biol. Chem. 248: 1609-1615. PMID 4144394.
- ↑ Wykle, R.L., Blank, M.L., Malone, B. and Snyder, F. (1972). „Evidence for a mixed function oxidase in the biosynthesis of ethanolamine plasmalogens from 1-alkyl-2-acyl-sn-glycero-3-phosphorylethanolamine”. J. Biol. Chem. 247: 5442-5447. PMID 4403444.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.