Peptidaza-55 razlaganja međuproizvoda
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| Peptidaza-55 razlaganja međuproizvoda | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.4.11.26 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Peptidaza-55 razlaganja međuproizvoda (EC 3.4.11.26, Icp55, peptidaza 55 kDa razlaganja mitohondrijskih intermedijera) je enzim.[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
- Ovaj enzim ralaže Pro36-Pro37 vezu cisteinske desumporaze (EC 2.8.1.7) čime se uklanjaju tri aminokiselinska ostatka (Tyr-Ser-Pro) sa N-terminusa nakon razlaganja mitohondrijskom peptidazom
Icp55 uklanja destabilizujuće N-terminalne aminokiselinske ostatke zaostale nakon razlaganja posredstvom mitohondrijske peptidaze.
Reference[uredi | uredi kod]
- ↑ Naamati, A., Regev-Rudzki, N., Galperin, S., Lill, R. and Pines, O. (2009). „Dual targeting of Nfs1 and discovery of its novel processing enzyme, Icp55”. J. Biol. Chem. 284: 30200-30208. PMID 19720832.
- ↑ Vogtle, F.N., Wortelkamp, S., Zahedi, R.P., Becker, D., Leidhold, C., Gevaert, K., Kellermann, J., Voos, W., Sickmann, A., Pfanner, N. and Meisinger, C. (2009). „Global analysis of the mitochondrial N-proteome identifies a processing peptidase critical for protein stability”. Cell 139: 428-439. PMID 19837041.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.