Peptid a-N-acetiltransferaza
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| Peptid a-N-acetiltransferaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.3.1.88 | ||||||||
| CAS broj | 116155-74-9 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Peptid a-N-acetiltransferaza (EC 2.3.1.88, beta-endorfinska acetiltransferaza, peptidna acetiltransferaza, proteinska N-terminalna acetiltransferaza, NAT, Nalfa-acetiltransferaza, enzim amino-terminalne amino kiselinske acetilacije, acetil-KoA:peptid alfa-N-acetiltransferaza) je enzim sa sistematskim imenom acetil-KoA:peptid Nalfa-acetiltransferaza.[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
- acetil-KoA + peptid KoA + Nalfa-acetilpeptid
Ovaj enzim acetiluje N-terminalni alanin, serin, metionin i glutamatne ostatake u brojnim peptidima i proteinima, uključujući beta-endorfine, kortikotropine i melanotropin, cf. [[EC 2.3.1.108] alfa-tubulin N-acetiltransferaza.
Reference[uredi | uredi kod]
- ↑ Driessen, H.P.C., Tesser, G.I. and Bloemendal, H. (1985). „The mechanism of N-terminal acetylation of proteins”. CRC Crit. Rev. Biochem. 18: 281-281. PMID 3902358.
- ↑ Glembotski, C.C. (1982). „Characterization of the peptide acetyltransferase activity in bovine and rat intermediate pituitaries responsible for the acetylation of β-endorphin and α-melanotropin”. J. Biol. Chem. 257: 10501-10509. PMID 6286657.
- ↑ O'Donohue, T.L. (1983). „Identification of endorphin acetyltransferase in rat brain and pituitary gland”. J. Biol. Chem. 258: 2163-2167. PMID 6296134.
- ↑ Tsunasawa, S., Kamitani, K. and Norita, K. (1980). „Partial purification and properties of the amino-terminal amino acid-acetylating enzyme from hen's oviduct”. J. Biochem. (Tokyo) 87: 645-650. PMID 6244269.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.