Pegfilgrastim
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| |
| (IUPAC) ime | |
|---|---|
| N-(3-Hidroksipropil)Metionil faktor stimulacije kolonije (ljudski), 1-Etar sa .alfa.-metil-.omega.-hidroksipoli(oksietilen)om | |
| Klinički podaci | |
| AHFS/Drugs.com | Monografija |
| Identifikatori | |
| CAS broj | 208265-92-3 |
| ATC kod | L03AA10 |
| DrugBank | DB00019 |
| UNII | 3A58010674 
|
| KEGG[1] | D06889
|
| ChEMBL[2] | CHEMBL1201568
|
| Hemijski podaci | |
| Formula | C845H1343N223O243S9 + PEG |
| Mol. masa | 39000 g/mol |
| Fizički podaci | |
| Tačka topljenja | 60 °C (140 °F) |
| Farmakokinetički podaci | |
| Poluvreme eliminacije | 15-80 h |
| Farmakoinformacioni podaci | |
| Trudnoća | ? |
| Pravni status | |
| Način primene | Subkutano |
Pegfilgrastim je pegilirana forma rekombinantnog analoga ljudskog stimulišućeg faktora granulocitne kolonije (GCSF) filgrastima. On se koristi za stimulaciju nivoa belih krvnih zrnaca (neutrofila).[3][4][5][6]
Reference[uredi | uredi kod]
- ↑ Joanne Wixon, Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast 17 (1): 48–55. DOI:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.
- ↑ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594.
- ↑ Walsh, G, Spada, S. "Epogen/Procrit" in: Directory of approved biopharmaceutical products. CRC Press, 2005, pp. 136-137.
- ↑ Yang BB, Kido A: Pharmacokinetics and pharmacodynamics of pegfilgrastim. Clin Pharmacokinet. 2011 May 1;50(5):295-306. doi: 10.2165/11586040-000000000-00000. PMID 21456630
- ↑ Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS (2011). „DrugBank 3.0: a comprehensive resource for omics research on drugs”. Nucleic Acids Res. 39 (Database issue): D1035-41. DOI:10.1093/nar/gkq1126. PMC 3013709. PMID 21059682.
- ↑ David S. Wishart, Craig Knox, An Chi Guo, Dean Cheng, Savita Shrivastava, Dan Tzur, Bijaya Gautam, and Murtaza Hassanali (2008). „DrugBank: a knowledgebase for drugs, drug actions and drug targets”. Nucleic Acids Res 36 (Database issue): D901-6. DOI:10.1093/nar/gkm958. PMC 2238889. PMID 18048412.
Literatura[uredi | uredi kod]
- Hardman JG, Limbird LE, Gilman AG. (2001). Goodman & Gilman's The Pharmacological Basis of Therapeutics (10 izd.). New York: McGraw-Hill. DOI:10.1036/0071422803. ISBN 0-07-135469-7.
- Thomas L. Lemke, David A. Williams, ur. (2007). Foye's Principles of Medicinal Chemistry (6 izd.). Baltimore: Lippincott Willams & Wilkins. ISBN 0-7817-6879-9.
