Pasireotid

Izvor: Wikipedia
Pasireotid
Klinički podaci
AHFS/Drugs.com Monografija
Identifikatori
CAS broj 396091-73-9
ATC kod H01CB05
PubChem[1][2] 9941444
DrugBank DB06663
ChEBI CHEBI:72312 YesY
Hemijski podaci
Formula C58H66N10O9 
Mol. masa 1107,26
SMILES eMolekuli & PubHem
Farmakokinetički podaci
Poluvreme eliminacije 12 h,
Farmakoinformacioni podaci
Trudnoća  ?
Pravni status
Način primene Subkutano

Pasireotid (SOM230, Signifor[3]) je orfanski lek koji je odobren u SAD i Evropi za lečenje Kušingove bolesti kod pacijenata kod kojih je hiruški zahvat neuspešan ili neprimenljiv.[4][5] Ovaj lek je razvilo preduzeće Novartis. Pasireotid je somatostatinski analog sa 40-puta većim afinitetom za somatostatinski receptor 5 nego za druge analoge somatostatinskog receptora.[6][7][8]

Reference[uredi - уреди]

  1. Li Q, Cheng T, Wang Y, Bryant SH (2010). "PubChem as a public resource for drug discovery.". Drug Discov Today 15 (23-24): 1052–7. doi:10.1016/j.drudis.2010.10.003. PMID 20970519.  edit
  2. Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). "Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities". Annual Reports in Computational Chemistry 4: 217–241. doi:10.1016/S1574-1400(08)00012-1. 
  3. Signifor (pasireotide) Official Website for healthcare professionals outside the US http://www.signifor.com/
  4. "Novartis drug Signifor® approved in the EU as the first medication to treat patients with Cushing's disease". http://finance.yahoo.com/news/novartis-drug-signifor-approved-eu-051703038.html;_ylt=A2KJ3CQ_5qBPSVwAuzLQtDMD. pristupljeno 8. 7. 2012.. 
  5. Mancini et al. Therapeutics and Clinical Risk Management 2010;6:505-516
  6. Weckbecker G, Briner U, Lewis I, Bruns C: SOM230: a new somatostatin peptidomimetic with potent inhibitory effects on the growth hormone/insulin-like growth factor-I axis in rats, primates, and dogs. Endocrinology. 2002 Oct;143(10):4123-30. PMID 12239124
  7. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS (2011). "DrugBank 3.0: a comprehensive resource for omics research on drugs". Nucleic Acids Res. 39 (Database issue): D1035–41. doi:10.1093/nar/gkq1126. PMC 3013709. PMID 21059682.  edit
  8. Nucleic Acids Res (2008). "DrugBank: a knowledgebase for drugs, drug actions and drug targets". Nucleic acids research 36 (Database issue): D901–6. doi:10.1093/nar/gkm958. PMC 2238889. PMID 18048412.  edit

Literatura[uredi - уреди]

Spoljašnje veze[uredi - уреди]

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