Paratiroidnom hormonu srodan protein

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Paratiroidnom hormonu srodan protein‎‎

PDB prikaz baziran na 1bzg.
Dostupne strukture
1BZG, 1M5N, 3FFD, 3H3G
Identifikatori
Simboli PTHLH; BDE2; HHM; PLP; PTHR; PTHRP
Vanjski ID OMIM168470 MGI97800 HomoloGene2113 GeneCards: PTHLH Gene
Pregled RNK izražavanja
PBB GE PTHLH 206300 s at tn.png
PBB GE PTHLH 211756 at tn.png
podaci
Ortolozi
Vrsta Čovek Miš
Entrez 5744 19227
Ensembl ENSG00000087494 ENSMUSG00000048776
UniProt P12272 Q924X4
RefSeq (mRNA) NM_002820.2 NM_008970.3
RefSeq (protein) NP_002811.1 NP_032996.2
Lokacija (UCSC) Chr 12:
28.11 - 28.13 Mb
Chr 6:
147.2 - 147.21 Mb
PubMed pretraga [1] [2]

Paratiroidnom hormonu srodan protein (PTHrP) je protein koji je član paratiroidne hormonske familije. U nekim slučajevima njega izlučuju ćelije kancera (rak dojke i pojedini tipova raka pluća). Međutim, on isto tako ima normalne funkcije.

Funkcija[uredi - уреди]

PTHrP deluje kao endokrini, autokrini, parakrini, i intrakrini hormon. On reguliše endohondralni razvoj kostiju putem održavanja endohondralnih rastućih ploča pri konstantnoj širini. On takođe reguliše epitelno-mesenhimalne interakcije tokom formiranja mlečnih žlezda.

Genetika[uredi - уреди]

Poznate su četiri alternativno splajsovane transkriptne varijante koji kodiraju dve različite izoforme. Postoji dokazi da dolazi od alternativne translacione inicijacije sa ne-AUG (CUG i GUG) početnih mesta.[1]

Interakcije[uredi - уреди]

Paratiroidnom hormonu srodan protein formira interakcije sa KPNB1[2][3] i arestin beta 1.[4]

Reference[uredi - уреди]

  1. "Entrez Gene: PTHLH parathyroid hormone-like hormone". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5744. 
  2. Cingolani, Gino; Bednenko Janna, Gillespie Matthew T, Gerace Larry (Dec. 2002). "Molecular basis for the recognition of a nonclassical nuclear localization signal by importin beta". Mol. Cell 10 (6): 1345–53. DOI:10.1016/S1097-2765(02)00727-X. ISSN 1097-2765. PMID 12504010. 
  3. Lam, M H; Hu W, Xiao C Y, Gillespie M T, Jans D A (Mar. 2001). "Molecular dissection of the importin beta1-recognized nuclear targeting signal of parathyroid hormone-related protein". Biochem. Biophys. Res. Commun. 282 (2): 629–34. DOI:10.1006/bbrc.2001.4607. ISSN 0006-291X. PMID 11401507. 
  4. Conlan, Lindus A; Martin T John, Gillespie Matthew T (Sep. 2002). "The COOH-terminus of parathyroid hormone-related protein (PTHrP) interacts with beta-arrestin 1B". FEBS Lett. 527 (1–3): 71–5. DOI:10.1016/S0014-5793(02)03164-2. ISSN 0014-5793. PMID 12220636. 

Literatura[uredi - уреди]

  • Miao D, Li J, Xue Y, Su H, Karaplis AC, Goltzman D (August 2004). "Parathyroid hormone-related peptide is required for increased trabecular bone volume in parathyroid hormone-null mice". Endocrinology 145 (8): 3554–62. DOI:10.1210/en.2003-1695. PMID 15090463. 
  • Casey ML, MacDonald PC (1997). "The endothelin-parathyroid hormone-related protein vasoactive peptide system in human endometrium: modulation by transforming growth factor-beta". Hum. Reprod. 11 Suppl 2: 62–82. PMID 8982748. 
  • Lam MH (2000). "Nuclear and nucleolar localization of parathyroid hormone-related protein". Immunol. Cell Biol. 78 (4): 395–402. DOI:10.1046/j.1440-1711.2000.00919.x. PMID 10947864. 
  • Fiaschi-Taesch NM, Stewart AF (2003). "Minireview: parathyroid hormone-related protein as an intracrine factor--trafficking mechanisms and functional consequences". Endocrinology 144 (2): 407–11. DOI:10.1210/en.2002-220818. PMID 12538599. 
  • Jans DA, Thomas RJ, Gillespie MT (2003). "Parathyroid hormone-related protein (PTHrP): a nucleocytoplasmic shuttling protein with distinct paracrine and intracrine roles". Vitam. Horm. 66: 345–84. DOI:10.1016/S0083-6729(03)01010-0. PMID 12852260. 
  • Maioli E, Fortino V, Pacini A (2005). "Parathyroid hormone-related protein in preeclampsia: a linkage between maternal and fetal failures". Biol. Reprod. 71 (6): 1779–84. DOI:10.1095/biolreprod.104.030932. PMID 15286039. 
  • Fenton AJ (1991). "A carboxyl-terminal peptide from the parathyroid hormone-related protein inhibits bone resorption by osteoclasts". Endocrinology 129 (4): 1762–8. DOI:10.1210/endo-129-4-1762. PMID 1915066. 
  • Fenton AJ (1991). "A potent inhibitor of osteoclastic bone resorption within a highly conserved pentapeptide region of parathyroid hormone-related protein; PTHrP[107-111]". Endocrinology 129 (6): 3424–6. DOI:10.1210/endo-129-6-3424. PMID 1954916. 
  • Moniz C (1991). "Parathyroid hormone-related peptide in normal human fetal development". J. Mol. Endocrinol. 5 (3): 259–66. DOI:10.1677/jme.0.0050259. PMID 2288637. 
  • Hammonds RG (1989). "Purification and characterization of recombinant human parathyroid hormone-related protein". J. Biol. Chem. 264 (25): 14806–11. PMID 2549037. 
  • Yasuda T, Banville D, Hendy GN, Goltzman D (1989). "Characterization of the human parathyroid hormone-like peptide gene. Functional and evolutionary aspects". J. Biol. Chem. 264 (13): 7720–5. PMID 2708388. 
  • Suva Lj (1989). "Structure of the 5' flanking region of the gene encoding human parathyroid-hormone-related protein (PTHrP)". Gene 77 (1): 95–105. DOI:10.1016/0378-1119(89)90363-6. PMID 2744490. 
  • Mangin M (1988). "Identification of a cDNA encoding a parathyroid hormone-like peptide from a human tumor associated with humoral hypercalcemia of malignancy". Proc. Natl. Acad. Sci. U.S.A. 85 (2): 597–601. DOI:10.1073/pnas.85.2.597. PMID 2829195. 
  • Moseley JM (1987). "Parathyroid hormone-related protein purified from a human lung cancer cell line". Proc. Natl. Acad. Sci. U.S.A. 84 (14): 5048–52. DOI:10.1073/pnas.84.14.5048. PMID 2885845. 
  • Mangin M, Ikeda K, Dreyer BE, Broadus AE (1989). "Isolation and characterization of the human parathyroid hormone-like peptide gene". Proc. Natl. Acad. Sci. U.S.A. 86 (7): 2408–12. DOI:10.1073/pnas.86.7.2408. PMID 2928340. 
  • Thiede MA (1988). "Human renal carcinoma expresses two messages encoding a parathyroid hormone-like peptide: evidence for the alternative splicing of a single-copy gene". Proc. Natl. Acad. Sci. U.S.A. 85 (13): 4605–9. DOI:10.1073/pnas.85.13.4605. PMID 3290897. 
  • Suva Lj (1987). "A parathyroid hormone-related protein implicated in malignant hypercalcemia: cloning and expression". Science 237 (4817): 893–6. DOI:10.1126/science.3616618. PMID 3616618. 
  • Campos RV, Zhang L, Drucker DJ (1995). "Differential expression of RNA transcripts encoding unique carboxy-terminal sequences of human parathyroid hormone-related peptide". Mol. Endocrinol. 8 (12): 1656–66. DOI:10.1210/me.8.12.1656. PMID 7708054. 
  • Holick MF (1994). "A parathyroid hormone antagonist stimulates epidermal proliferation and hair growth in mice". Proc. Natl. Acad. Sci. U.S.A. 91 (17): 8014–6. DOI:10.1073/pnas.91.17.8014. PMID 8058749. 
  • Seitz PK (1993). "Parathyroid hormone-related peptide production and action in a myoepithelial cell line derived from normal human breast". Endocrinology 133 (3): 1116–24. DOI:10.1210/en.133.3.1116. PMID 8396010. 
  • Li H (1996). "Effect of endogenously produced parathyroid hormone-related peptide on growth of a human hepatoma cell line (Hep G2)". Endocrinology 137 (6): 2367–74. DOI:10.1210/en.137.6.2367. PMID 8641188.