Pantetein-fosfat adenililtransferaza

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Pantetein-fosfat adenililtransferaza
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Identifikatori
EC broj 2.7.7.3
CAS broj 9026-99-7
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures

Pantetein-fosfat adenililtransferaza (EC 2.7.7.3, defosfo-KoA pirofosforilaza, pantetein fosfat adenililtransferaza, defosfo-koenzim A pirofosforilaza, 3'-defosfo-KoA pirofosforilaza) je enzim sa sistematskim imenom ATP:pantetein-4'-fosfat adenililtransferaza.[1][2][3][4][5] Ovaj enzim katalizuje sledeću hemijsku reakciju

ATP + pantetein 4'-fosfat \rightleftharpoons difosfat + 3'-defosfo-KoA

Enzim iz nekoliko bakterija (e.g. Escherichia coli, Bacillus subtilis i Haemophilus influenzae) je bifunkcionalan.

Reference[uredi - уреди]

  1. Hoagland, M.B. and Novelli, G.D. (1954). "Biosynthesis of coenzyme A from phosphopantetheine and pantetheine from pantothenate". J. Biol. Chem. 207: 767–773. PMID 13163064. 
  2. Novelli, G.D. (1953). "Enzymatic synthesis and structure of CoA". Fed. Proc. 12: 675–682. PMID 13107738. 
  3. Martin, D.P. and Drueckhammer, D.G. (1993). "Separate enzymes catalyze the final two steps of coenzyme A biosynthesis in Brevibacterium ammoniagenes: purification of pantetheine phosphate adenylyltransferase". Biochem. Biophys. Res. Commun. 192: 1155–1161. PMID 8389542. 
  4. Geerlof, A., Lewendon, A. and Shaw, W.V. (1999). "Purification and characterization of phosphopantetheine adenylyltransferase from Escherichia coli". J. Biol. Chem. 274: 27105–27111. PMID 10480925. 
  5. Izard, T., Geerlof, A., Lewendon, A. and Barker, J.J. (1999). "Cubic crystals of phosphopantetheine adenylyltransferase from Escherichiacoli". Acta Crystallogr. D Biol. Crystallogr. 55: 1226–1228. PMID 10329792. 

Literatura[uredi - уреди]

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