Oprelvekin
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| Klinički podaci | |
|---|---|
| Robne marke | Neumega, Neumega (Genetics Institute Inc) |
| AHFS/Drugs.com | Monografija |
| Identifikatori | |
| CAS broj | 145941-26-0 |
| ATC kod | L03AC02 |
| DrugBank | DB00038 |
| ChEMBL[1] | CHEMBL1201573 
|
| Hemijski podaci | |
| Formula | ? |
| Mol. masa | 0,000 |
| Farmakokinetički podaci | |
| Poluvreme eliminacije | 6,9 +/- 1,7 h |
| Farmakoinformacioni podaci | |
| Trudnoća | ? |
| Pravni status | |
| Način primene | Subkutano |
Oprelvekin je rekombinantni interleukin 11 (IL-11),[2] faktor rasta koji direktno stimuliše proliferaciju hematopoietskih matičnih ćelija i progenitornih ćelija megakariocita i indukuje sazrevanje megakariocita, što dovodi do povećane produkcije trombocita.[3][4] Ovaj lek je u prodaji pod imenom Neumega.
Reference[uredi | uredi kod]
- ↑ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594.
- ↑ Cantor SB, Elting LS, Hudson DV, Rubenstein EB (June 2003). „Pharmacoeconomic analysis of oprelvekin (recombinant human interleukin-11) for secondary prophylaxis of thrombocytopenia in solid tumor patients receiving chemotherapy”. Cancer 97 (12): 3099–106. DOI:10.1002/cncr.11447. PMID 12784347.
- ↑ Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS (2011). „DrugBank 3.0: a comprehensive resource for omics research on drugs”. Nucleic Acids Res. 39 (Database issue): D1035-41. DOI:10.1093/nar/gkq1126. PMC 3013709. PMID 21059682.
- ↑ David S. Wishart, Craig Knox, An Chi Guo, Dean Cheng, Savita Shrivastava, Dan Tzur, Bijaya Gautam, and Murtaza Hassanali (2008). „DrugBank: a knowledgebase for drugs, drug actions and drug targets”. Nucleic Acids Res 36 (Database issue): D901-6. DOI:10.1093/nar/gkm958. PMC 2238889. PMID 18048412.
Literatura[uredi | uredi kod]
- Hardman JG, Limbird LE, Gilman AG. (2001). Goodman & Gilman's The Pharmacological Basis of Therapeutics (10 izd.). New York: McGraw-Hill. DOI:10.1036/0071422803. ISBN 0-07-135469-7.
- Thomas L. Lemke, David A. Williams, ur. (2007). Foye's Principles of Medicinal Chemistry (6 izd.). Baltimore: Lippincott Willams & Wilkins. ISBN 0-7817-6879-9.
