Norbuprenorfin
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| |||
| (IUPAC) ime | |||
|---|---|---|---|
| (5α,6β,14β,18R)-18-[(1S)-1-hydroxy-1,2,2-trimethylpropyl]-6-methoxy-18,19-dihydro-4,5-epoxy-6,14-ethenomorphinan-3-ol | |||
| Klinički podaci | |||
| Identifikatori | |||
| CAS broj | 78715-23-8 | ||
| ATC kod | nije dodeljen | ||
| PubChem[1][2] | 6426801 | ||
| ChemSpider[3] | 4932224 | ||
| Hemijski podaci | |||
| Formula | C25H35NO4 | ||
| Mol. masa | 413.55 g/mol | ||
| SMILES | eMolekuli & PubHem | ||
| |||
| Farmakoinformacioni podaci | |||
| Trudnoća | ? | ||
| Pravni status | |||
Norbuprenorfin je primarni aktivni metabolit buprenorfina. Norbuprenorfin deluje kao pun agonist μ-opioidnog, δ-opioidnog, i nociceptinskog receptora,[4][5] kao i parcijalni agonist κ-opioidnog receptora.[5] Norbuprenorfin prolazi kroz krvno-moždanu barijeru slično buprenorfinu i verovatno doprinosi njegovom dejstvu.[6]
Vidi još[uredi | uredi kod]
Literatura[uredi | uredi kod]
- ↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519.
- ↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
- ↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846.
- ↑ Yassen A, Kan J, Olofsen E, Suidgeest E, Dahan A, Danhof M (May 2007). „Pharmacokinetic-pharmacodynamic modeling of the respiratory depressant effect of norbuprenorphine in rats”. The Journal of Pharmacology and Experimental Therapeutics 321 (2): 598–607. DOI:10.1124/jpet.106.115972. PMID 17283225.
- ↑ 5,0 5,1 Huang P, Kehner GB, Cowan A, Liu-Chen LY (May 2001). „Comparison of pharmacological activities of buprenorphine and norbuprenorphine: norbuprenorphine is a potent opioid agonist”. The Journal of Pharmacology and Experimental Therapeutics 297 (2): 688–95. PMID 11303059.
- ↑ Jensen ML, Foster D, Upton R, Grant C, Martinez A, Somogyi A (April 2007). „Comparison of cerebral pharmacokinetics of buprenorphine and norbuprenorphine in an in vivo sheep model”. Xenobiotica; the Fate of Foreign Compounds in Biological Systems 37 (4): 441–57. DOI:10.1080/00498250701251126. PMID 17455115.
