Neuropilin 1

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Neuropilin 1

PDB prikaz baziran na 1kex.
Dostupne strukture
1KEX, 2QQI, 2QQM, 2QQN, 3I97, 4DEQ
Identifikatori
Simboli NRP1; BDCA4; CD304; NP1; NRP; VEGF165R
Vanjski ID OMIM602069 MGI106206 HomoloGene2876 GeneCards: NRP1 Gene
Pregled RNK izražavanja
PBB GE NRP1 212298 at tn.png
PBB GE NRP1 210510 s at tn.png
PBB GE NRP1 210615 at tn.png
podaci
Ortolozi
Vrsta Čovek Miš
Entrez 8829 18186
Ensembl ENSG00000099250 ENSMUSG00000025810
UniProt O14786 P97333
RefSeq (mRNA) NM_001024628.2 NM_008737.2
RefSeq (protein) NP_001019799.1 NP_032763.2
Lokacija (UCSC) Chr 10:
33.47 - 33.63 Mb
Chr 8:
128.36 - 128.51 Mb
PubMed pretraga [1] [2]

Neuropilin-1 je protein koji je kod ljudi kodiran NRP1 genom.[1][2][3] On je jedan od dva ljudska neuropilina.

NRP1 je za membranu vezan koreceptor receptora tirozinske kinaze za vaskularni endotelni faktor rasta (VEGF; MIM 192240) i članove familije semaforina (SEMA3A; MIM 603961). NRP1 ima više uloga u angiogenezi, navođenju aksona, ćelijskom opstanku, migraciji, i invaziji.[3]

Interakcije[uredi - уреди]

Neuropilin 1 formira interakcije sa vaskularnim endotelnim faktorom rasta A.[1][4]

Reference[uredi - уреди]

  1. 1.0 1.1 Soker S, Takashima S, Miao HQ, Neufeld G, Klagsbrun M (April 1998). "Neuropilin-1 is expressed by endothelial and tumor cells as an isoform-specific receptor for vascular endothelial growth factor". Cell 92 (6): 735–45. doi:10.1016/S0092-8674(00)81402-6. PMID 9529250. 
  2. Chen H, Chedotal A, He Z, Goodman CS, Tessier-Lavigne M (November 1997). "Neuropilin-2, a novel member of the neuropilin family, is a high affinity receptor for the semaphorins Sema E and Sema IV but not Sema III". Neuron 19 (3): 547–59. doi:10.1016/S0896-6273(00)80371-2. PMID 9331348. 
  3. 3.0 3.1 "Entrez Gene: NRP1 neuropilin 1". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8829. 
  4. Mamluk, Roni; Gechtman Ze'ev, Kutcher Matthew E, Gasiunas Nijole, Gallagher John, Klagsbrun Michael (Jul. 2002). "Neuropilin-1 binds vascular endothelial growth factor 165, placenta growth factor-2, and heparin via its b1b2 domain". J. Biol. Chem. (United States) 277 (27): 24818–25. doi:10.1074/jbc.M200730200. ISSN 0021-9258. PMID 11986311. 

Literatura[uredi - уреди]