Natamicin

Izvor: Wikipedia
Natamicin
Klinički podaci
Robne marke Natacyn, Pimaricin
AHFS/Drugs.com Monografija
Identifikatori
CAS broj 7681-93-8
ATC kod A01AB10 , S01AA10
PubChem[1][2] 5281099
DrugBank DB00826
KEGG[3] C08073 YesY
Hemijski podaci
Formula C33H47NO13 
Mol. masa 665,725
SMILES eMolekuli & PubHem
Fizički podaci
Tačka topljenja 290 °C (554 °F)
Farmakoinformacioni podaci
Trudnoća  ?
Pravni status
Način primene Oftalmički

Natamicin je organsko jedinjenje, koje sadrži 33 atoma ugljenika i ima molekulsku masu od 665,725 Da.[4][5]

Osobine[uredi - уреди]

Osobina Vrednost
Broj akceptora vodonika 14
Broj donora vodonika 7
Broj rotacionih veza 3
Particioni koeficijent[6] (ALogP) -2,8
Rastvorljivost[7] (logS, log(mol/L)) -5,1
Polarna površina[8] (PSA, Å2) 231,0

Reference[uredi - уреди]

  1. Li Q, Cheng T, Wang Y, Bryant SH (2010). "PubChem as a public resource for drug discovery.". Drug Discov Today 15 (23-24): 1052–7. doi:10.1016/j.drudis.2010.10.003. PMID 20970519.  edit
  2. Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). "Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities". Annual Reports in Computational Chemistry 4: 217–241. doi:10.1016/S1574-1400(08)00012-1. 
  3. Joanne Wixon, Douglas Kell (2000). "Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG". Yeast 17 (1): 48–55. doi:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H. 
  4. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS (2011). "DrugBank 3.0: a comprehensive resource for omics research on drugs". Nucleic Acids Res. 39 (Database issue): D1035–41. doi:10.1093/nar/gkq1126. PMC 3013709. PMID 21059682. 
  5. Nucleic Acids Res (2008). "DrugBank: a knowledgebase for drugs, drug actions and drug targets". Nucleic acids research 36 (Database issue): D901–6. doi:10.1093/nar/gkm958. PMC 2238889. PMID 18048412. 
  6. Ghose, A.K., Viswanadhan V.N., and Wendoloski, J.J. (1998). "Prediction of Hydrophobic (Lipophilic) Properties of Small Organic Molecules Using Fragment Methods: An Analysis of AlogP and CLogP Methods". J. Phys. Chem. A 102: 3762–3772. doi:10.1021/jp980230o. 
  7. Tetko IV, Tanchuk VY, Kasheva TN, Villa AE. (2001). "Estimation of Aqueous Solubility of Chemical Compounds Using E-State Indices". Chem Inf. Comput. Sci. 41: 1488–1493. doi:10.1021/ci000392t. PMID 11749573. 
  8. Ertl P., Rohde B., Selzer P. (2000). "Fast calculation of molecular polar surface area as a sum of fragment based contributions and its application to the prediction of drug transport properties". J. Med. Chem. 43: 3714–3717. doi:10.1021/jm000942e. PMID 11020286. 

Literatura[uredi - уреди]

Spoljašnje veze[uredi - уреди]

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