Nardilizin
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| Nardilizin | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.4.24.61 | ||||||||
| CAS broj | 292850-69-2 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Nardilizin (EC 3.4.24.61, N-arginin dibazna konvertaza, NRD-konvertaza) je enzim.[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
- Hidroliza polipeptida, preferentno u -Xaa-Arg-Lys-, i u manjoj meri -Arg-Arg-Xaa-, pri čemu Xaa nije Arg ili Lys
Ovaj enzim je prisutan u mozgu i testisima pacova.
Reference[uredi | uredi kod]
- ↑ Gomez, S., Gluschankof, P., Morel, A. and Cohen, P. (1985). „The somatostatin-28 convertase of rat brain cortex is associated with secretory granule membranes”. J. Biol. Chem. 260: 10541-10545. PMID 3897221.
- ↑ Gluschankof, P., Gomez, S., Morel, A. and Cohen, P. (1987). „Enzymes that process somatostatin precursors. A novel endoprotease that cleaves before the arginine-lysine doublet is involved in somatostatin-28 convertase activity of rat brain cortex”. J. Biol. Chem. 262: 9615-9620. PMID 2885328.
- ↑ Chesneau, V., Pierotti, A.R., Barré, N., Créminon, C., Tougard, C. and Cohen, P. (1994). „Isolation and characterization of a dibasic selective metalloendopeptidase from rat testes that cleaves at the amino terminus of arginine residues”. J. Biol. Chem. 269: 2056-2061. PMID 8294457.
- ↑ Pierotti, A.R., Prat, A., Chesneau, V., Gaudoux, F., Leseney, A.-M., Foulon, T. and Cohen, P. (1994). „N-Arginine dibasic convertase, a metalloendopeptidase as a prototype of a class of processing enzymes”. Proc. Natl. Acad. Sci. USA 91: 6078-6082. PMID 8016118.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.