Nalmekson
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| |||
| (IUPAC) ime | |||
|---|---|---|---|
| (5α)-3,14-dihidroksi-17-(3-metil-2-buten-1-il)-4,5-epoksimorfinan-6-on | |||
| Klinički podaci | |||
| Identifikatori | |||
| CAS broj | 16676-26-9 16291-05-7 (HCl) | ||
| ATC kod | nije dodeljen | ||
| PubChem[1][2] | 5360516 | ||
| ChemSpider[3] | 4514525 | ||
| Hemijski podaci | |||
| Formula | C21H25NO4 | ||
| Mol. masa | 355,428 g/mol | ||
| SMILES | eMolekuli & PubHem | ||
| |||
| Farmakoinformacioni podaci | |||
| Trudnoća | ? | ||
| Pravni status | |||
Nalmekson (INN; EN-1620A, UM-592, nalmekson hidrohlorid) je semisintetički, mešoviti opioidni agonist-antagonist sa analgetičkim i narkotičnim svojstvima.[4][5][6][7] U kliničkim ispitivanjima utvrđeno je da ima analgetičku efikastnost sličnu morfinu, mada sa nekoliko puta umanjenom potentnošću.[8] Osim toga, nuspojave nalmeksona su pospanost i znojenje, slično morfinu, mada u znatnom većem stepenu i učestalošću.[8]
Reference[uredi | uredi kod]
- ↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519.
- ↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
- ↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846.
- ↑ F.. Macdonald (1997). Dictionary of Pharmacological Agents. CRC Press. str. 1395. ISBN 978-0-412-46630-4. Pristupljeno 11. 5. 2012.
- ↑ Casy, Alan F.; Parfitt, Robert T. (1986). Opioid Analgesics: Chemistry and Receptors. Springer. str. 55. ISBN 978-0-306-42130-3. Pristupljeno 11. 5. 2012.
- ↑ Loew GH, Berkowitz DS (January 1978). „Quantum chemical studies of N-substituent variation in the oxymorphone series of opiate narcotics”. Journal of Medicinal Chemistry 21 (1): 101–6. PMID 73588.
- ↑ Forrest WH, Shroff PF, Mahler DL (1972). „Analgesic and other effects of nalmexone in man”. Clinical Pharmacology and Therapeutics 13 (4): 520–5. PMID 4557582.
- ↑ 8,0 8,1 National Research Council (U.S.). Committee on Problems of Drug Dependence; American Medical Association. Committee on Alcoholism and Drug Dependence; American Medical Association. Council on Mental Health; National Academy of Sciences (U.S.) (1969*). Bulletin, problems of drug dependence. National Academies. str. 5873. NAP:10503. Pristupljeno 11. 5. 2012.
Literatura[uredi | uredi kod]
- National Research Council (U.S.). Committee on Problems of Drug Dependence; American Medical Association. Committee on Alcoholism and Drug Dependence; American Medical Association. Council on Mental Health; National Academy of Sciences (U.S.) (1969*). Bulletin, problems of drug dependence. National Academies. str. 5873. NAP:10503. Pristupljeno 11. 5. 2012.
- Casy, Alan F.; Parfitt, Robert T. (1986). Opioid Analgesics: Chemistry and Receptors. Springer. str. 55. ISBN 978-0-306-42130-3. Pristupljeno 11. 5. 2012.
- F.. Macdonald (1997). Dictionary of Pharmacological Agents. CRC Press. str. 1395. ISBN 978-0-412-46630-4. Pristupljeno 11. 5. 2012.
