Naftoatna sintaza
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| Naftoatna sintaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
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| Naftoatna sintaza hexamer, Mycobacterium tuberculosis | |||||||||
| Identifikatori | |||||||||
| EC broj | 4.1.3.36 | ||||||||
| CAS broj | 61328-42-5 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Naftoatna sintaza (EC 4.1.3.36, 1,4-dihidroksi-2-naftoatna sintaza, dihidroksinaftoatna sintaza, o-sukcinilbenzoil-KoA 1,4-dihidroksi-2-naftoatna-lijaza (ciklizacija), MenB, o-sukcinilbenzoil-KoA dehidrataza (ciklizacija)) je enzim sa sistematskim imenom 4-(2-karboksifenil)-4-oksobutanoil-KoA dehidrataza (ciklizacija).[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
- 4-(2-karboksifenil)-4-oksobutanoil-KoA 1,4-dihidroksi-2-naftoil-KoA + H2O
Ovaj enzim učestvuje u sintezi 1,4-dihidroksi-2-naftoata.
Reference[uredi | uredi kod]
- ↑ Meganathan, R. and Bentley, R. (1979). „Menaquinone (vitamin K2) biosynthesis: conversion of o-succinylbenzoic acid to 1,4-dihydroxy-2-naphthoic acid by Mycobacterium phlei enzymes”. J. Bacteriol. 140: 92-98. PMID 500558.
- ↑ Kolkmann, R. and Leistner, E. (1987). „4-(2′-Carboxyphenyl)-4-oxobutyryl coenzyme A ester, an intermediate in vitamin K2 (menaquinone) biosynthesis”. Z. Naturforsch. C: Sci. 42: 1207-1214. PMID 2966501.
- ↑ Johnson, T.W., Shen, G., Zybailov, B., Kolling, D., Reategui, R., Beauparlant, S., Vassiliev, I.R., Bryant, D.A., Jones, A.D., Golbeck, J.H. and Chitnis, P.R. (2000). „Recruitment of a foreign quinone into the A(1) site of photosystem I. I. Genetic and physiological characterization of phylloquinone biosynthetic pathway mutants in Synechocystis sp. pcc 6803”. J. Biol. Chem. 275: 8523-8530. PMID 10722690.
- ↑ Truglio, J.J., Theis, K., Feng, Y., Gajda, R., Machutta, C., Tonge, P.J. and Kisker, C. (2003). „Crystal structure of Mycobacterium tuberculosis MenB, a key enzyme in vitamin K2 biosynthesis”. J. Biol. Chem. 278: 42352-42360. PMID 12909628.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.