N-metil-2-oksoglutaramatna hidrolaza
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| N-metil-2-oksoglutaramatna hidrolaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.5.1.36 | ||||||||
| CAS broj | 9073-53-4 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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N-metil-2-oksoglutaramatna hidrolaza (EC 3.5.1.36, 5-hidroksi-N-metilpiroglutamatna sintaza) je enzim sa sistematskim imenom N-metil-2-oksoglutaramat metilamidohidrolaza.[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
- N-metil-2-oksoglutaramat + H2O 2-oksoglutarat + metilamin
U reverznoj reakciji se produkt ciklizuje neenzimitski do 2-hidroksi-N-metil-5-oksoprolina.
Reference[uredi | uredi kod]
- ↑ Hersh, L.B. (1970). „5-Hydroxy-N-methylpyroglutamate synthetase. Purification and mechanism of action”. J. Biol. Chem. 245: 3526-3535. PMID 5470822.
- ↑ Hersh, L.B., Tsai, L. and Stadtman, E.R. (1969). „The enzymatic synthesis of 5-hydroxy-N-methylpyroglutamic acid”. J. Biol. Chem. 244: 4677-4683. PMID 5808511.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.