N-acetilfosfatidiletanolamin-hidrolizujuća fosfolipaza D
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| N-acetilfosfatidiletanolamin-hidrolizujuća fosfolipaza D | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.1.4.54 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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N-acetilfosfatidiletanolamin-hidrolizujuća fosfolipaza D (EC 3.1.4.54, NAPE-PLD, anandamid-generišuća fosfolipaza D, N-acil fosfatidiletanolaminska fosfolipaza D, NAPE-hidrolizujuća fosfolipaza D) je enzim sa sistematskim imenom N-acetilfosfatidiletanolamin fosfatidohidrolaza.[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
- N-acilfosfatidileetanolamin + H2O N-aciletanolamin + 1,2-diacilglicerol 3-fosfat
Ovaj enzim učestvujeu u biosintezi anandamida.
Reference[uredi | uredi kod]
- ↑ Okamoto, Y., Morishita, J., Tsuboi, K., Tonai, T. and Ueda, N. (2004). „Molecular characterization of a phospholipase D generating anandamide and its congeners”. J. Biol. Chem. 279: 5298-5305. PMID 14634025.
- ↑ Wang, J., Okamoto, Y., Morishita, J., Tsuboi, K., Miyatake, A. and Ueda, N. (2006). „Functional analysis of the purified anandamide-generating phospholipase D as a member of the metallo-β-lactamase family”. J. Biol. Chem. 281: 12325-12335. PMID 16527816.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.